Background: The aim of our study was to determine the association low levels pregnancy associated plasma protein-A (PAPP-A) estimated at 11-13+6weeks gestation with fetal growth restriction (FGR).Methods: A prospective observational a total 203 pregnant women PAPP-A were followed up and outcome data collected childbirth.Results: incidence FGR 7.3%. significant found between MoM (≤0.49) (p=0.000...

OBJECTIVE To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE). METHODS Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected control...

A selection of artificial neural network models were built and implemented for systematically study the contribution and the sensitivity of the main influencing parameters as important contributing factors for the noninvasive prediction of chromosomal abnormalities. The parameters that had been investigated are: the previous medical history of the pregnant mother, the nasal bone, the tricuspid ...

Insight into the mechanisms of intestinal transport and metabolism of aspalathin will provide important information for dose optimisation, in particular for studies using mouse models. Aspalathin transportation across the intestinal barrier (Caco-2 monolayer) tested at 1-150 µM had an apparent rate of permeability (Papp) typical of poorly absorbed compounds (1.73 × 10-6 cm/s). Major glucose tra...

OBJECTIVE To establish normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in southern Thai women, and to compare these reference levels with Caucasian-specific and northern Thai models. METHODS A cross-sectional study was conducted in 1,150 normal singleton pregnancy women to determine serum pregnancy-associated plasma protein-A...

OBJECTIVE To examine the performance of screening for trisomies 21, 18 and 13 at 11-13 weeks' gestation using specific algorithms for these trisomies based on combinations of fetal nuchal translucency thickness (NT), fetal heart rate (FHR), ductus venosus pulsatility index for veins (DV PIV), and serum free β-human chorionic gonadotropin (β-hCG), pregnancy-associated plasma protein A (PAPP-A), ...

OBJECTIVE We aimed to detect whether maternal serum free β-hCG and PAPP-A levels and NT measurements vary between normal pregnancies and those that subsequently develop pre-eclampsia and to evaluate the role of these screening serum analytes in the prediction of pre-eclampsia. METHODS Using a case-control study design, we identified all women who had been screened by double test within 11+0 a...

OBJECTIVE To assess the impact of a vanishing twin on the levels of the biochemical markers used in the first trimester aneuploidy screening. METHODS A retrospective analysis of free beta-hCG and PAPP-A levels in 270 women with a normal singleton fetus with ultrasound evidence of a vanishing twin pregnancy. Marker levels (as MoM) were compared in three groups-76 women with a second empty gest...

Background and Objective The atherosclerotic plaque vulnerability may be related to inflammation, immunity, metabolism and blood clotting. One of the key factors affecting plaque stability is inflammatory reaction. This study was to investigate the relationship between vulnerability of coronary artery plaque evaluated with coronary angiography (CAG), intravascular ultrasound (IVUS) and the leve...

BACKGROUND Adverse gestational outcomes such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are associated with placental insufficiency. Normal placental development relies on the insulin-like growth factors -I and -II (IGF-I and -II), in part to stimulate trophoblast proliferation and extravillous trophoblast (EVT) migration. The insulin-like growth factor binding proteins (IG...