نتایج جستجو برای: p53 expression

تعداد نتایج: 898809  

Journal: :Journal of virology 2013
Yuhei Maruzuru Hikaru Fujii Masaaki Oyama Hiroko Kozuka-Hata Akihisa Kato Yasushi Kawaguchi

p53 is a critical factor in the cellular response to a broad range of stress factors through its ability to regulate various cellular pathways. In this study, tandem affinity purification of transiently expressed herpes simplex virus 1 (HSV-1) regulatory protein ICP22 coupled with mass spectrometry-based proteomics technology and subsequent analyses showed that ICP22 interacted with p53 in HSV-...

Journal: :The Journal of clinical investigation 2011
Yongxing Wang Young-Ah Suh Maren Y Fuller James G Jackson Shunbin Xiong Tamara Terzian Alfonso Quintás-Cardama James A Bankson Adel K El-Naggar Guillermina Lozano

The transcription factor p53 is a tumor suppressor. As such, the P53 gene is frequently altered in human cancers. However, over 80% of the P53 mutations found in human cancers are missense mutations that lead to expression of mutant proteins that not only lack p53 transcriptional activity but exhibit new functions as well. Recent studies show that restoration of p53 expression leads to tumor re...

2012
Bi-He Cai Pei-Ching Hsu I-Lun Hsin Chung-Faye Chao Mei-Hua Lu Hwang-Chi Lin Shih-Hwa Chiou Pao-Luh Tao Jang-Yi Chen

During epidermal cell differentiation, keratin 14 (K14) expression is down-regulated, p53 expression varies, and the expression of the p53 target genes, p21 and 14-3-3σ, increases. These trends suggest that the relative transcriptional activity of p53 is increased during epidermal cell differentiation. To determine the relationship between K14 and p53, we constructed K14 promoters of various si...

Journal: :European journal of cancer 2012
Jiangbo Liu Qingyong Ma Min Zhang Xinshuai Wang Dong Zhang Wei Li Fengfei Wang Erxi Wu

BACKGROUND The prognostic significance of p53 aberration in hepatocellular carcinoma (HCC) remains inconclusive. This systematic review and meta-analysis aimed to provide comprehensive evidence on the association of p53 alterations with recurrence-free survival (RFS) and overall survival (OS) in HCC patients. METHODS Systematic literature searches were conducted until July 2010. Meta-analysis...

Journal: : 2021

We investigated the effects of melatonin, cetuximab and cisplatin treatments alone or in combination on PANC-1 cells from a human pancreatic carcinoma ductal cell origin through viability gene expressions. The were left for 48 h incubation after applying chemicals cells. metabolic substances at end measured by MTT assay. expressions p21, p27, p53, p57, MDM2 KRAS determined RT-PCR. use melatonin...

2017
Xiaowei Wang Wei Lv Fang Qi Zhiqiang Gao Hua Yang Weiqing Wang Yali Gao

BACKGROUND The level of p53 protein expression in sinonasal squamous cell carcinoma (SNSCC) has been estimated, but the results remain inconsistent and the point of consensus has not been reached. This study was first determined to evaluate the clinical effects of p53 expression in SCC of the sinonasal tract. METHODS According to the preferred reporting items for systematic reviews and meta-a...

2007
Sung-Chul Lim Tae-Beum Lee Cheol-Hee Choi So-Yeon Ryu Kyung-Jong Kim Young-Don Min

PURPOSE Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests that COX-2 expression is normally suppressed by wild-type p53 but not mutant p53, suggesting that loss of p53 function may result in the induction of COX-2 expression. The aim of thi...

2005
Dae Sung Cho Hee Jae Joo Dong Keun Oh Ji Hun Kang Young Soo Kim Kyi Beom Lee Se Joong Kim

The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 and p53 expression with prognosis in patients with conventional renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 92 patients, who had undergone radical nephrectomy, were examined for COX-2 and p53 expression by immunohistochemistry and compared with clinicopa...

2017
Jianguo Yang Zhaohui Zhao Xingming Zhong

Glioma is a common type of brain and neurological cancer with high degree of malignancy. Expression of p53 has been found in a variety of tumor cells and VEGF has been associated with the angiogenesis in cancers. In this study, the expressions of p53 and VEGF in glioma were examined. The relationship between clinicopathological features of glioma and the expression profiles of p53 and VEGF was ...

Journal: :Molecular cancer research : MCR 2017
Kyrie Pappas Jia Xu Sakellarios Zairis Lois Resnick-Silverman Francesco Abate Nicole Steinbach Sait Ozturk Lao H Saal Tao Su Pamela Cheung Hank Schmidt Stuart Aaronson Hanina Hibshoosh James Manfredi Raul Rabadan Ramon Parsons

TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depleti...

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