The paradigm of phenotypic plasticity indicates reversible relations of different cancer cell phenotypes, which extends the cellular hierarchy proposed by the classical cancer stem cell (CSC) theory. Since it is still questionable if the phenotypic plasticity is a crucial improvement to the hierarchical model or just a minor extension to it, it is worthwhile to explore the dynamic behavior char...

Citation Cueto-Felgueroso, L., and R. Juanes. " A phase field model of unsaturated flow. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. [1] We present a phase fie...

In glucose-limited aerobic chemostat cultures of a wild-type Saccharomyces cerevisiae and a derived hxk2 null strain, metabolic fluxes were identical. However, the concentrations of intracellular metabolites, especially fructose 1,6-bisphosphate, and hexose-phosphorylating activities differed. Interestingly, the hxk2 null strain showed a higher maximal growth rate and higher Crabtree threshold ...

There is preliminary evidence that there are several types of submovements in movement aiming that reflect different processes of control and can result from particular task constraints. The purpose of the study was to investigate the effect of movement space and time task criteria on the prevalence of different submovement control characteristics in discrete aiming. Twelve participants complet...

The action of halothane on sinoatrial, ventricular, and Purkinje fibers was studied by means of intracellular microelectrodes. Rabbit atrial fibers were not very sensitive to even high (2%) concentrations of halothane. Sheep Purkinje fibers showed a significant hyperpolarization from 82 mv to 87 mv, a marked shortening of the duration of the action potential from 370 msec to 233 msec, and a dim...

By using the periodic signal present in the frequencies of oscillation due to the base of the solar convection zone, Monteiro, Christensen-Dalsgaard & Thompson (1994) gave an upper limit to the extent of a layer of convective overshooting in the Sun. Alternative studies (Roxburgh & Vorontsov, 1994) have suggested that it may not be possible to do so since the amplitude of the signal does not va...

We undertake a detailed mathematical analysis of a recent nonlinear ordinary differential equation (ODE) model describing the chemotactic signalling cascade within an Escherichia coli cell. The model includes a detailed description of the cell signalling cascade and an average approximation of the receptor activity. A steady-state stability analysis reveals the system exhibits one positive real...

OBJECTIVE Therapeutic hypothermia has become a standard neuroprotective treatment in term newborn infants following perinatal asphyxia. Active cooling with whole body surface or head cooling is complex, expensive and often associated with initial hypothermic overshoot. We speculated that passive cooling might suffice to induce and maintain hypothermia. METHODS We analysed 18 asphyxiated term ...