The Brattleboro rat carries as a recessive trait the inability to synthesize hypothalamic vasopressin and its related neurophysin but is able to synthesize oxytocin and its neurophysin. Brattleboro rats homozygous for this trait have no immunologically detectable circulating vasopressin and manifest a complete syndrome of diabetes insipidus, which is corrected with vasopressin replacement thera...

KUROKAWA, KIYOSHI, AND SHAUL G. MASSRY. Interaction between catecholamines and vasopressin on renal medullary cyclic AMP of rat. Am. J. Physiol. 225(4) : 825-829. 1973.-The effects of catecholamines, alphaand beta-adrenergic blockers, and the interaction between these agents and vasopressin on cyclic AMP concentration in suspensions of isolated cortical and medullary tubules of rat kidney were ...

BACKGROUND The hypothalamic neuropeptide arginine vasopressin is thought to play an important role in the pathophysiology of affective disorders and the hyperactivity of the hypothalamic-pituitary-adrenocortical system that frequently accompanies them. Postmortem studies as well as clinical investigations have described elevated levels of vasopressin in the brain and plasma of depressed patient...

Proximal duodenal bicarbonate secretion is an important factor in humans and animals protecting the mucosa against acid-peptic damage. This study examined the mechanisms responsible for the central nervous system regulation of duodenal bicarbonate secretion by calcitonin gene-related peptide (CGRP) in unrestrained rats. Cerebroventricular administration of rat CGRP significantly inhibited basal...

Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. ...

Arginine vasopressin is elevated in congestive heart failure. To determine the effect of arginine vasopressin upon systemic hemodynamics and regional blood flows, we administered the specific inhibitor of the vascular action of vasopressin [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-(O-methyl)-tyrosine]-arginine vasopressin [d(CH2)5Tyr(Me)AVP] to 15 dogs with chronic right-...

Crit Care Resuscitation ISSN: 1441-2772 4 September 2006 8 3 239-240 © C r i t C a r e R es u s c i t a t i on 20 06 www.jficm.anzca.edu.au/aaccm/journal/publications.htm Points of view retic hormone, and is deficient in patients w shock. It is therefore being increasingly consid alternative or additional vasopressor therapy patients. Small cases series and a small pha suggest it as clinical be...

VASOPRESSIN ANATOMY OF THE MOUSE BRAIN FEBRUARY 2010 BENJAMIN D. ROOD, B.S., BATES COLLEGE M.S., UNIVERSITY OF MASSACHUSETTS AMHERST Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Geert J. de Vries The nine amino acid peptide vasopressin acts as a neurohormone in the periphery and a neurotransmitter / neuromodulator in the central nervous system. Historically, research on vasopressin n...

A plasma membrane fraction was prepared from pig kidney medulla. It contained lysine-vasopressin-sensitive adenylate cyclase activity (maximum activation: 4to 6fold, apparent Km value for the hormone: about 5 X 1OV M). Lysine-vasopressin was not inactivated by the membrane preparation even at low hormonal concentrations. The specific [3H]lysine-vasopressin (vasopressin) binding sites found are ...

Hypothesis / aims of study Sex hormones have a pronounced effect on arginine vasopressin (AVP), and therefore on the diurnal water homeostasis. The structural resemblance of oxytocin to AVP has likewise led to speculations of a possible additive antidiuretic effect of oxytocin (1). Prostaglandin E2 (PGE-2) counteracts the effect of AVP on water reabsorption and will be elevated when the concent...