An efficient isocyanide-based synthesis of S-thiocarbamates was discovered and thoroughly investigated. The new reaction protocol is a one-pot procedure allows the direct conversion N-formamides into thiocarbamates by initial dehydration with p-toluene sulfonyl chloride to respective isocyanide subsequent addition sulfoxide component. Contrary recent literature, which also uses isocyanides as s...

(-)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (-)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (-)-Ambrox is still unavailable at present although a lot of attention has been paid to this hot research topic for many years. A one-pot synthesis of...

Bismuth metal–organic frameworks (MOFs) as heterogeneous catalysts are scarce, and there is little knowledge on the influence of MOF features their resulting activity behavior. Here, we present synthesis, characterization, catalytic in one-pot multicomponent Strecker reaction with ketones three new MOFs prepared combination indium or bismuth 4,4′,4′′,4′′′-methanetetrayltetrabenzoic acid. One th...

The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported. series were generated using a “one-pot” MCR, leading single regioisomer of the attempted heteroaromatic skeleton in good yields. Next, functionalization C-5 and C-6 positions was investigated. (Het)aryl groups introduced at regioselective electrophilic brominations followed by Suzuki–Miyaura cross coupling re...

al-mcm-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. the reaction was efficiently promoted by 10 mg nano-al-mcm-41 and the heterogeneous catalyst was recycled for four runs in this reaction with...

a facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in etoh has been developed. 3-thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. better results...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

A hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na–bentonite with cetyltrimethyl ammonium bromide (CTMAB) cations. The catalyst was characterized by XRD, BET and SEM. The...