The ability of human spermatozoa to exhibit sperm-oocyte fusion in response to the ionophore, A23187, was examined in relation to the capacity of these cells to generate reactive oxygen species. In 70 fertile control donors, there was an overwhelming pattern of high levels of sperm-oocyte fusion associated with low levels of reactive oxygen species production. By contrast, 88% of the 74 oligozo...

To evaluate the clinical efficacy of a procedure comprising a combination of Percoll continuous density gradient and modified swim-up techniques for the removal of human immunodeficiency virus type 1 (HIV-1) from the semen of HIV-1 infected males, a total of 129 couples with an HIV-1 positive male partner and an HIV-1 negative female partner (serodiscordant couples) who were treated at Keio Uni...

A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenotypic consequence, these mutations could be fixed as stable mtDNA variants, because mtDNA is matern...

Objective: To determine an association of single nucleotide polymorphism the NRF2 gene (RS6721961) with semen parameters primary male infertility patients in Pakistani population.
 Study Design: Comparative cross-sectional study.
 Place and Duration Study: Department Biochemistry, Islamic International Medical College, Rawalpindi, collaboration two private clinics (American Infertilit...

Background: Although chemotherapy drugs used in treatment of cancer such as lukemia, prostate and ovary cancer and oligospermia is important contraceptive of this drugs therefore this drugs are author of infertility or low fertility in specimen. In the other hand, the studies show that melatonin is secreted from pineal gland has a direct efficacy on the gonads. The aim of this study was to inve...

Abstract Background Much interest has not been placed on the role of chromosomal abnormalities in pathogenesis and rising prevalence infertility recent times. This review was conducted to renew public basis infertility, testing, management. Main text Meiotic post-zygotic mitotic errors may cause infertility-predisposing abnormalities, including Klinefelter syndrome, Jacob Triple X Turner Down s...