More than 170 million individuals worldwide are infected with hepatitis C virus (HCV), and up to an estimated 30% of chronically infected individuals will go on to develop progressive liver disease. Despite the recent advances in antiviral treatment of HCV infection, it remains a major public health problem. Thus, development of an effective vaccine is urgently required. In this study, we const...

The ccns3Sim project is an open source implementation of the CCNx 1.0 protocols for the NS3 [2] simulator. We describe the implementation and several important features including modularity and process delay simulation. The ccns3Sim implementation is a fresh NS3-specific implementation. Like NS3 itself, it uses C++98 standard, NS3 code style, NS3 smart pointers, NS3 xUnit, and integrates with t...

The hepatitis C virus (HCV) multifunctional nonstructural protein 3 (NS3) is a protease that cleaves viral and host proteins and a helicase that separates DNA and RNA structures in reactions fueled by ATP hydrolysis. Li et al. (2012) recently synthesized a series of new NS3 helicase inhibitors from the benzothiazole dimer component of the fluorescent yellow dye primuline. This study further cha...

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 August 2022 on 182 who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals Medan, Indonesia. The...

Background: Human Givens (HG) Rewind is a relatively unknown trauma-focussed treatment. This paper aimed to provide preliminary evidence of the effectiveness treat posttraumatic stress (PTS) in variety clinical settings Great Britain. Methods: An observational prospective design was used each four studies. Standardised questionnair...

Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and associated with neuroinflammation neuropsychiatric disorders, including disruption of sleep/wake patterns, now recognised as a circadian disorder. traditionally studied using murine models infection due to lack alternative in vitro</ns3:it...

Background: The aim of this study was to perform a comparative evaluation 5% Sodium fluoride varnish, neutral nano silver (NSF) varnish and acidulated in remineralising artificially induced enamel caries primary teeth. Methods: 39 anterior teeth were sectioned 2mm below the cemento-enamel junction (CEJ) mounted acrylic resin blocks...

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution ...

Background: HIV/AIDS is still a major public health issue around the world, especially in Sub-Saharan Africa (SSA), where this has resulted unquantifiable human suffering, social and cultural disruption, enormous economic losses. Methods: This study aims to assess women’s knowledge attitude toward its prevention Ghana.<ns3:...

Many viral proteins undergo proteolytic processing events that are required for virus infection and virion assembly. In this issue of Biochemical Journal, Strongin and co-workers report that the NS3 protease from West Nile virus unexpectedly cleaves certain substrates at pairs of basic residues, a specificity that resembles that of the furin-like PCs (proprotein convertases). This led to the de...