نتایج جستجو برای: nrf

تعداد نتایج: 1068  

Journal: :The Journal of biological chemistry 2011
Claude A Piantadosi Crystal M Withers Raquel R Bartz Nancy Chou MacGarvey Ping Fu Timothy E Sweeney Karen E Welty-Wolf Hagir B Suliman

The induction of heme oxygenase-1 (HO-1; Hmox1) by inflammation, for instance in sepsis, is associated both with an anti-inflammatory response and with mitochondrial biogenesis. Here, we tested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcription factor, links anti-inflammatory cytokine expression to activation of mitochondrial biogenesis. HO-1 induction after LPS stimulated anti-...

2016
Changbo Shen Wei Cheng Pingping Yu Li Wang Lulin Zhou Li Zeng Qin Yang

There is considerable interest in the use of drugs and other methods for protecting implanted neural stem cells (NSCs) from the adverse environment of injured tissue for successful cell therapy. Resveratrol can modify cardiac stem cells to enhance their survival and differentiation, however, its effect and the mechanism underlying its neuroprotective effect on NSCs following stroke remain to be...

2017
Xiali Zhong Rita de Cássia da Silveira e Sá Caigao Zhong

Hexavalent chromium (Cr(VI)) is a ubiquitous environmental pollutant, which poses a threat to human public health. Recent studies have shown that mitochondrial biogenesis can be activated by inflammatory and oxidative stress. However, whether mitochondrial biogenesis is involved in Cr(VI)-induced hepatotoxicity is unclear. Here, we demonstrated the induction of inflammatory response and oxidati...

2016
Daniel A. Franco Seth Truran Volkmar Weissig Diana Guzman‐Villanueva Nina Karamanova Subhadip Senapati Camelia Burciu Marina Ramirez‐Alvarado Luis M. Blancas‐Mejia Stuart Lindsay Parameswaran Hari Raymond Q. Migrino

BACKGROUND Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothesis that nanoliposomes composed of monosialoganglioside, phosphatidylcholine, ...

Journal: :Journal of Immunology 2023

Abstract Secreted airway mucins form a mucous gel consisting of MUC5AC and MUC5B maintain homeostasis for appropriate mucociliary clearance defense. There is conceivably global mechanism to counteract excessive mucin production in response incessant exposure external internal stimuli, which otherwise leads goblet metaplasia mucus hyperproduction. Here, we report that butyrate, short-chain fatty...

Journal: :Journal of the Iranian Statistical Society 2021

The authors would like to hereby acknowledge the support of StatDisT group. This work is based upon research supported by National Research foundation South Africa, Reference: SRUG 190308422768 grant number 120839, IFR170227223754 109214 and SARCHI Chair UID: 71199. opinions expressed conclusions arrived at are those not necessarily be attributed NRF.

Journal: :Circulation research 2015
Li-Jing Chen Li Chuang Yi-Hsuan Huang Jing Zhou Seh Hong Lim Chih-I Lee Wei-Wen Lin Ting-Er Lin Wei-Li Wang Linyi Chen Shu Chien Jeng-Jiann Chiu

RATIONALE In atherosclerotic lesions, synthetic smooth muscle cells (sSMCs) induce aberrant microRNA (miR) profiles in endothelial cells (ECs) under flow stagnation. Increase in shear stress induces favorable miR modulation to mitigate sSMC-induced inflammation. OBJECTIVE To address the role of miRs in sSMC-induced EC inflammation and its inhibition by shear stress. METHODS AND RESULTS Cocu...

Journal: :The Australian journal of physiotherapy 2002
Charbel Badr Mark R Elkins Elizabeth R Ellis

Positioning combined with coughing and huffing is frequently used to promote secretion clearance. Maximum expiratory pressure (MEP) and peak expiratory flow rate (PEFR) have been used as surrogate measures of cough and huff strength. This study investigated the effect of body position on MEP and PEFR. Repeated measures of MEP and PEFR were performed across seven randomised positions (standing, ...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2010
J I Orczewska G Hartleben K M O'Brien

We sought to determine the molecular basis of elevations in aerobic metabolic capacity in the oxidative muscle and liver of Gasterosteus aculeatus in response to cold acclimation. Fishes were cold- or warm-acclimated for 9 wk and harvested on days 1, 2, and 3 and weeks 1, 4, and 9 of cold acclimation at 8 degrees C, and on day 1 and week 9 of warm acclimation at 20 degrees C. Mitochondrial volu...

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