نتایج جستجو برای: neurotoxins

تعداد نتایج: 3862  

Journal: :Current topics in medicinal chemistry 2015
Gyanendra Kumar Subramanyam Swaminathan

Botulinum Neurotoxins are the most poisonous of all toxins with lethal dose in nanogram quantities. They are potential biological warfare and bioterrorism agents due to their high toxicity and ease of preparation. On the other hand BoNTs are also being increasingly used for therapeutic and cosmetic purposes, and with that the chances of accidental overdose are increasing. And despite the potent...

Journal: :The Biochemical journal 1981
H S Kim N Tamiya

The venom of an Australian elapid snake, the common death adder (Acanthophis antarcticus), was chromatographed on a CM-cellulose CM52 column. One of the neurotoxic components, Acanthophis antarcticus b (toxin Aa b) was isolated in about 9.4% (A280) yield. The complete amino acid sequence of toxin Aa b was elucidated. Toxin Aa b is composed of 73 amino acid residues, with ten half-cystine residu...

2007
J. Larsen Niccole J. Larsen Donald B. DeFranco Timothy Greenamyre Ruth G. Perez Bryan K. Yamamoto Teresa G. Hastings

Background and Objectives: Study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. In this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (CA1) was examined by the studying the hippocampal tissue. Materials and Methods: Injections of colchicine (1-75 μg/rat, intra- hippocampal CA1) were performed in cannulated male Wistar rat...

Journal: :Proceedings of the National Academy of Sciences 1975

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