background: preterm labor is at risk for respiratory distress syndrome (rds) and sometimes requires to mechanical ventilation (mv) and surfactant therapy. continuous positive airway pressure (cpap) and nasal continuous positive airway pressure (ncpap) are the methods of respiratory support especially for using in rds of neonates. in other method surfactant is administered to babies via tracheal...

objective: neonatal  jaundice (nj)  is  one of the  most  common  cause  of  neonatal  hospital  admission.  phototherapy is the main therapy for hyperbilirubinemia of neonatal jaundice. the efficacy of phototherapy depends on the dose and wavelength of light used and the surface area exposed. we  increased  photons  in  mirror  covered  tunnel  phototherapy  (mctp)  by  putting  mirrors behind...

Diseases caused by gene haploinsufficiency in humans commonly lack a phenotype in mice that are heterozygous for the orthologous factor, impeding the study of complex phenotypes and critically limiting the discovery of therapeutics. Laboratory mice have longer telomeres relative to humans, potentially protecting against age-related disease caused by haploinsufficiency. Here, we demonstrate that...

The SM6C10 IgM autoantibody recognizes a surface determinant, 6C10, that is highly expressed on all immature thymocytes. In contrast, its expression on peripheral T cells appears developmentally regulated, i.e., absent from most naive T cells in spleen of neonatal mice, but expressed on 40-80% of naive CD4+ T cells in adult. In this paper, we demonstrate that SM6C10 recognizes a carbohydrate ep...

BACKGROUND Oxygen may damage the lung directly via generation of reactive oxygen species (ROS) or indirectly via the recruitment of inflammatory cells, especially neutrophils. Overexpression of extracellular superoxide dismutase (EC-SOD) has been shown to protect the lung against hyperoxia in the newborn mouse model. The CXC-chemokine receptor antagonist (Antileukinate) successfully inhibits ne...

CD8+ cytotoxic T cells play a critical role in initiating insulin-dependent diabetes mellitus. The relative contribution of each of the major cytotoxic pathways, perforin/granzyme and Fas/Fas ligand (FasL), in the induction of autoimmune diabetes remains controversial. To evaluate the role of each lytic pathway in beta cell lysis and induction of diabetes, we have used a transgenic mouse model ...