The binding of glucagon-like peptide 1 (GLP-1) incretin hormone and its receptor GLP-1R plays an important role in the human body. GLP-1 acts as insulin secretion stimulator through a agonist activation to avoid type 2 diabetes mellitus problem. A recent development computational sciences has enabled us design new mutant which better stability GLP-1R. In this paper, we have conducted in-depth a...