S-phase kinase-associated protein 2 (SKP2) gene is a tumor suppressor gene, and is involved in the ubiquitin-mediated degradation of P27kip1. SKP2 and P27kip1 affect the proceeding and prognosis of leukemia through regulating the proliferation, apoptosis and differentiation of leukemia cells. In this study, we explored the mechanism of reversing of HL-60/A drug resistance through SKP2 down-regu...

conclusions all the staphylococcus aureus strains and enterococcus faecium strains were sensitive to members of the oxazolidinone class of linezolid drug. development of multi drug resistance by gram positive bacteria constitutes a very serious challenge for medical practice. despite these rising rates, it is impossible to distinguish where they have originated from and special attention has th...

Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...

Background: In the present study two hundred milk samples were collected from cows and buffaloes with no history of clinical mastitis in ongoing lactation, Sirohi district Southern Rajasthan. Methods: The pooled sample (collected each quarter) examined for status subclinical by Modified California test Somatic cell count respectively. Positive further investigated isolation identification major...

background: tuberculosis is one of the infectious diseases worldwide that has resurgence by the aids epidemic and led to the rise of drug-resistant tuberculosis patients. thus, it seems essential to monitor the drug susceptibility in tuberculosis patients. the new high resolution melting (hrm) method is simple, rapid and inexpensive for detection of the mutations responsible for drug resistance...

INTRODUCTION Acinetobacter baumannii is opportunistic in debilitated hospitalised patients. Because information from some South American countries was previously lacking, this study examined the emergence of multi-resistant A. baumannii in three hospitals in Cochabamba, Bolivia, from 2008 to 2009. METHODOLOGY Multiplex PCR was used to identify the main resistance genes in 15 multi-resistant A...

multi drug resistance(mdr) is a major problem in the treatment of cancer and hemalological malignancies. this resistance is multi factorial and is the result of decreased intra cellular drug accumulation. this is partly due to the presence of a 170kd intra membranous protein termed p-glycoprotein(p-gp) that is an energy-dependent efflux pump which has increased expression on drug-resistance cel...