"-Proline, "H-asparagine and Na2W04 have been found to be highly specific markers for axonal transport in the goldfish visual system. The amino acids label both rapidly and slowly transported proteins while the 35S is recovered mainly with the rapidly transported materials, including protein-bound mucopolysaccharides. These precursors have been used to study the rate of transport, the subcellul...

Intrinsic factor can bind vitamin B12 and simultaneously attach to receptors on liver or small intestine in a calcium-dependent manner (1). There appears to be a stoichiometric relationship between the receptors, intrinsic factor and vitamin B12 (2). This report, previously presented in preliminary form (3), is concerned with blocking of the receptor sites for hog intrinsic factor by human gast...

Acid mucopolysaccharides have been found in urine (1) but have not been consistently demonstrated in the blood of normal subjects. Bassiouni (2) recently isolated a substance from leukocytes which he noted to be similar to chondroitin sulfate. In our laboratory leukocytes have been found to contain appreciable quantities of a substance resembling chondroitin sulfate. A direct relationship betwe...

The histopathology of the posterior half of one eye and the optic nerves of a man with Hunter's syndrome, who was known to have disc oedema without raised intracranial pressure for 11 years of his life, is reported. The possible pathogenesis of the disc oedema is discussed; an important contributory factor was the deposition of abnormal mucopolysaccharides within the sclera. This caused gross t...