Statins are efficient cholesterol-lowering medicines utilized worldwide. However, 10% of patients suffer from adverse effects specially related to skeletal muscle function. Pro- or anti-oxidant effects of statins have been reported. Here we hypothesized that statins induce muscle mitochondrial oxidative stress leading to mitochondrial permeability transition (MPT) which may explain statin muscl...

The mitochondrial permeability transition (MPT) mediates hepatic necrosis after ischemia and reperfusion (I/R). Here, we studied the role of c-Jun N-terminal kinase 2 (JNK2) in MPT-induced liver injury. Wildtype (WT) and JNK2 knockout (KO) mice underwent 70% liver ischemia for 1 hr followed by reperfusion for 8 hr, after which hepatocyte injury and animal survival was assessed. Compared with WT...

According to the Memory for Past Test (MPT) heuristic, judgments of learning (JOLs) may be based, in part, on memory for the correctness of answers on a previous test. The authors explored MPT as the source of the underconfidence with practice effect (UWP; A. Koriat, L. Sheffer, & H. Ma'ayan, 2002), whereby Trial 1 overconfidence switches to underconfidence by Trial 2. Immediate and delayed JOL...

Abstract The concept of Quaternary average conditions has gained popularity over the past few decades, especially with studies long-term landscape evolution. In this paper, we critically assess by analyzing marine isotope record (LR04 δ 18 O stack) relative to Quaternary. This shows that frequency and amplitude climate glacial-interglacial cycles are not constant throughout Quaternary, a clear ...

A fully thermomechanical coupled phase-field (PF) model is presented to investigate the mechanism of austenite-to-martensite phase transformation (MPT) and crack initiation as well its propagation in pure austenitic microstructures. The latent heat release absorption involved MPT are explicitly taken into account by coupling PF with transient transfer. In order consider temperature dependency f...

Multinomial processing tree (MPT) modeling is a statistical methodology that has been widely and successfully applied for measuring hypothesized latent cognitive processes in selected experimental paradigms. This paper concerns model complexity of MPT models. Complexity is a key and necessary concept to consider in the evaluation and selection of quantitative models. A complex model with many p...

N-Alkyl perfluorooctane sulfonamides have been widely used as surfactants on fabrics and papers, fire retardants, and anticorrosion agents, among many other commercial applications. The broad use, global distribution, and environmental persistence of these compounds has generated considerable interest regarding potentially toxic effects. We have previously reported that perfluorooctanesulfonami...

BlL, a galactose-binding C-type lectin purified from Bothrops leucurus snake venom, exhibits anticancer activity. The current study was designed to elucidate the cellular mechanisms by which BlL induces melanoma cell death. The viabilities of B16-F10 melanoma cells and HaCaT keratinocytes treated with BlL were evaluated. Necrotic and apoptotic cell death, cytosolic Ca(2+) levels, mitochondrial ...