The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain amo...

The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic potential for liver and intestinal inflammatory diseases. We aim to identify and...

Topical steroids are known for their anti-inflammatory properties and are commonly prescribed to treat many adverse skin conditions such as eczema and psoriasis. While these treatments are known to be effective, adverse effects including skin atrophy are common. In this study, the progression of these effects is investigated in an in vivo mouse model using multimodal optical microscopy. Utilizi...

A sensitive stability-indicating reversed-phase high performance liquid chromatographic method was developed for the simultaneous determination of mometasone furoate (MON), oxymetazoline (OXY), phenyl ethanol (PEL) and benzalkonium chloride analogs (BKC1and BKC2) in nasal spray solution. The chromatographic separation was achieved on Cosmosil CN 150 mm x 4.6mm, 5 um column Using a mobile phase ...

Introduction: Allergic rhinitis is an inflammatory disorder of the nose which occurs when the membranes lining the nose become sensitised to allergens. Although not classed as a life-threatening disease, allergic rhinitis can reduce the patient’s quality of life. Mometasonefuroate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of th...

CONCLUSION An inflammatory swelling in the uvula and nose due to vibration might be a contributing factor in snoring. The presence of corticosteroid receptors in the uvula indicates the possibility for treatment with local steroids. Use of mometasone furoate (MF) for 3 months reduced snoring and related symptoms in some patients. OBJECTIVE To investigate the effect of a nasal steroid, MF, on ...