Histamine has positive inotropic and chronotropic effects on the heart which are not abolished by beta adrenergic-blocking agents. Since the positive inotropic and chronotropic effects of other hormones on the heart are thought to be mediated by cyclic 3',5'-AMP, we examined the effect of histamine on adenyl cyclase in particulate preparations of guinea pig, cat, and human myocardium. Histamine...

igure 1 Endoscopic image of the sole showing multiple lightrown to black coloured moles. Long term use of thiopurines in the treatment of inflammatory bowel disease (IBD) is associated with the development of non-melanoma skin cancer. Here we present a patient who developed unusual skin abnormalities during azathioprine administration. A 22-year-old woman with known Crohn's disease (located at ...

BACKGROUND Fires, explosions, and extreme heat production may occur when sevoflurane reacts with desiccated barium hydroxide lime. The identity of the flammable gas has not previously been published, although carbon monoxide, methanol, formaldehyde, and methyl formate have been identified in low quantities. METHODS The authors reacted sevoflurane with excess desiccated barium hydroxide lime o...

A more complete study of ionic concentrations and fluxes in the giant internodal cells of Nitella translucens has been made. The vacuolar concentrations were 76 mM K and 170 mM C1. The content of the chloroplast layer was 135 m#moles K/cm 2 and 215 m/~moles C1/cm2; in a layer 9 # thick these correspond to concentrations of 150 mM K and 240 rn~ C1. Such a high level of chloride requires active t...