Linkage studies have defined at least five bipolar (BP) disorder susceptibility loci that meet suggested guidelines for initial identification and subsequent confirmation. These loci, found on 18p11, 18q22, 21q21, 4p16, and Xq26, are targets for BP candidate gene investigations. Molecular dissection of expressed sequences for these regions is likely to yield specific BP susceptibility alleles i...

Indian population is characterized by wide diversity and unique population structure shaped by different waves of migration and the practice of caste endogamy. Anthropologists have been studying the peopling of India and the relationships between different populations using traditional genetic markers. With the advent of molecular genetic techniques the focus has turned to using the DNA polymor...

A 2.7-kilobase DNA fragment carrying the entire exotoxin A (ETA) structural gene was divided into three nonoverlapping probes. Two probes covering the ETA structural gene were used in colony hybridization experiments to determine whether sequences homologous to the ETA gene could be detected in genera other than Pseudomonas or in Pseudomonas species other than Pseudomonas aeruginosa. The majori...

This paper describes a range of theoretical studies into the likely properties of poly-nitrogen molecules (Nn, n>3). In particular, we describe the approach we have used to assess the potential detonation performance of this class of material, and illustrate this with a number of example calculations. We also discuss the implications and limitations of these predictions. In addition, we describ...

Highly purified preparations of D-aIIIiII0 acid oxidase were obtained by removal of high molecular weight components after purification by established procedures. Molecular sieve studies were carried out on the size characterization of the highly purified apoenzyme molecule. In the microgram per ml concentration range the apoenzyme was shown to dissociate to a subunit with a molecular Stokes ra...

Chromosome heteromorphisms, restriction fragment length polymorphisms, or both were used to study the parental origin of 33 cases of simple trisomy 13 and eight cases of translocation trisomy 13. The most common origin for the simple trisomies was non-disjunction at maternal meiosis I, while for the translocations an equal number of paternally and maternally derived cases was observed. In seven...

Genetic aberrations in sarcomas 10 2.1. Cytogenetic alterations 10 2.2. Molecular genetic changes 13 2.2.1. Structural alterations of cellular proto-oncogenes 13 2.2.2. Gene amplifications 13 2.2.3. Alterations of tumor suppressor genes and loss of 17 DNA sequences 2.3. Hereditary predisposition 18 3. DNA amplification 19 3.1. Structure and mechanisms of DNA amplification 20 4. Methods for dete...

We present an analysis of relationships in Gilliesioideae (Alliaceae) based on a combined matrix of plastid rbcL, the trnL intron, the trnL-F intergenic spacer, and the rpsl6 intron and nuclear ITS ribosomal DNA sequences. The results are generally congruent with previous analyses, indicating two well-supported groups: Ipheion plus allied genera ("lpheieae" ined.) and Gilliesieae. They also pro...

In the Fermionic Molecular Dynamics (FMD) approach many-body wave functions are described by Slater determinants of Gaussian wave-packets localized in phase space. The symmetries of the Hamiltonian are restored by projection on parity, angular and linear momentum. An effective interaction derived from the realistic Argonne V18 interaction by explicit introduction of short-range central and tens...