OBJECTIVE To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia. METHODS Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34+0 weeks of gestation (early-onset preeclampsia) and ≥ 34+0 weeks of gestation (late-onset preeclampsia). For each case in each of the preeclampsia subgroups,...

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5-8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called "a disease of theories." The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analy...

OBJECTIVE To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women. METHODS Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia. RESULTS The risk of preeclampsia varied from 7% in obese primipara...

1. Abstract 2. Introduction 3. Sodium Regulation in Uncomplicated Pregnancy 4. Sodium Regulation in Preeclampsia 5. Cell Sodium Regulation in Uncomplicated Pregnancy 5.1. Cell Sodium and Cell (Na,K)ATPase or Sodium Pump (SP) in Uncomplicated Pregnancy 5.2. Other Cell Sodium Transport Systems in Uncomplicated Pregnancy 6. Cell Sodium Regulation in Preeclampsia 6.1. Cell Sodium and Potassium in P...

Shah, Dinesh M. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol 288: F614–F625, 2005; doi:10.1152/ ajprenal.00410.2003.—Preeclampsia is a hypertensive disorder unique to pregnancy with consistent involvement of the kidney. The renin-angiotensin system (RAS) has been implicated in the pathogenesis of preeclampsia. In the gravid state, in addit...

BACKGROUND Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our s...

Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational...

Preeclampsia is a hypertensive disorder unique to pregnancy with consistent involvement of the kidney. The renin-angiotensin system (RAS) has been implicated in the pathogenesis of preeclampsia. In the gravid state, in addition to the RAS in the kidney, there is a tissue-based RAS in the uteroplacental unit. Increased renin expression observed both in human preeclampsia and in a transgenic mous...

Brenner1 recently reviewed thrombophilia-related placental vascular complications, notably including preeclampsia and intrauterine growth restriction, and dealt baldly with the question of the potential benefit of aspirin in prevention of preeclampsia, claiming it was raised and refuted in the 1980s. Of course, when preeclampsia occurs in association with factor V (FV) Leiden mutation, factor I...