midazolam (dormicum) is a benzodiazepine in general anesthesia. midazolam is very suitable for premedication, induction, and maintenance pronounced anxiolytic action, sedation and amnesia, rapid onset of the action, virtually no impairment of cardiovascular or respiratory parameters in therapeutic doses, short duration of action, and excellent local tolerance are among its most important effect...

BackgroundAlthough midazolam and ketamine are widely administrated as oral premedications for children, only a few studies have investigated the cardiovascular, respiratory and sedative effects of these drugs in children with congenital heart disease (CHD). MethodsWe compared three methods of administering midazolam and ketamine and a combination of these two drugs as an oral premedication in 1...

This study was undertaken to compare the induction characteristics of conventional thiopentone sodium, midazolam, and a combination of midazolam and thiopentone sodium as co-induction agent. Total one hundred and fifty patients of ASA grade I and II were divided into three groups in a double blind randomized study. Group-I received midazolam 0.25 mgkg-1 intravenously, group–II received thiopent...

CITATION Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedeto midine for Long-Term Sedation Investigators: Dexmedetomidine vesus midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 2012, 307:1151-1160. BACKGROUND Long-term sedation with midazolam or propofol in intensive care units (I...

BACKGROUND Restless and violent behaviors are common in Emergency Departments (EDs), which need therapeutic interventions in most of the times. The first-generation anti-psychotic drugs are one of the most applicable therapeutic agents in the management of such patients, but their use has some limitations. Some studies suggest midazolam as an alternative medicine. Therefore, this study was perf...

BACKGROUND Sedation for surgical procedures performed with regional or local anesthesia has usually been achieved with intravenous medications, whereas the use of volatile anesthetics has been limited. The use of sevoflurane for sedation has been suggested because of its characteristics of nonpungency, rapid induction, and quick elimination. The purpose of this investigation was to assess the q...

OBJECTIVE To compare the efficacy of continuous intravenous sedation with midazolam alone vs. midazolam plus fentanyl ("co-sedation") during mechanical ventilation. DESIGN A randomized, prospective, controlled trial. SETTING A ten-bed medical intensive care unit at a university hospital. PATIENTS Thirty patients with respiratory failure who were expected to require >48 hrs of mechanical v...

We compared the efficacy of intranasal midazolam, ketamine and their mixture as premedication in children with tetralogy of Fallot (TOF) using bispectral index (BIS), sedation score and separation score at the time of separation from parent. Sedation score at the time of intravenous cannulation was also measured. Children with TOF physiology were randomly divided into three equal groups of 20 e...

Three experiments investigated the effects of midazolam on acquisition of fear-mediated analgesic responses in rats conditioned on the heated floor of a hot-plate apparatus. Experiment 1 demonstrated that a moderate dose (1.25 mg/kg) of midazolam administered prior to conditioning impaired acquisition of conditioned analgesia in rats retested on the heated floor 24 h later. This effect of midaz...