While hot melt extrusion is now established within the pharmaceutical industry, the prediction of miscibility, processability and structural stability remains a pertinent issue, including the issue of whether molecular interaction is necessary for suitable performance. Here we integrate the use of theoretical and experimental drug-polymer interaction assessment with determination of processabil...

The current work aims to develop environmentally friendly plastic materials by preparing a composite polypropylene/thermoplastic starch (PP/TPS) using melt-compounding process. In order improve the compatibility of two naturally incompatible polymers, natural Stipa tenacissima fibers treated on their surfaces and polypropylene (PP) pellets grafted with Maleic Anhydride (MA) were added mixture (...

1. Supplemental Methods Page Testing the performance of MELT in new compute environments 2 Generation of simulated data sets and validation of MELT features 2 Quality tranche system 2 Sensitivity, specificity, and runtime of MELT and other algorithms 3 Generation of MELT MEI call sets 3 PCR validation of MELT 3 Identification of population-specific Alu subfamilies 4 Assessment of Alu allelic he...

Background and Objective One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aimed to develop an SD formulation with ibuprofen, a poor water-soluble BC...

In the present study, the properties of polycaprolactone (PCL) and wood flour (WF) blends were examined by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), Instron mechanical tester, and scanning electron microscopy (SEM). As for results, the mechanical properties of PCL were lowered obviously, due to the poor compatibility between the two phases, when it...

The aim of this study was to prepare nanostructured lipid carriers (NLC)-based topical gel of aceclofenac for the treatment of inflammation and allied conditions. Stearic acid as the solid lipid, oleic acid as the liquid lipid, pluronic F68 as the surfactant, and phospholipon 90G as the co-surfactant were used. NLCs were prepared by melt-emulsification, low-temperature solidification, and high-...

Polymeric nanocomposites based on polyethylene (PE) and Brazilian natural montmorillonite clay (MN) were obtained by melt processing, using a twin-screw extruder. The main objective of this work is focusing on the characterization of composites materials by solid-state nuclear magnetic resonance (NMR). The solid-state NMR measurements were used to observe both polymer matrix (through carbon-13 ...

In this study, a pulp beating machine was used to premix the pulp fibers with high density polyethylene (HDPE) particles in water. The wet or pre-dried pulp fiber/HDPE mixture was then melt-compounded by a twin screw extruder. For further improving the dispersion of pulp fiber, some mixture was forced to pass through the twin-screw extruder twice. The resulting mixture was compression molded to...

This study presents the utilization of oil palm ash (OPA), a siliceous material from the fiber of oil palm biomass, as a nanofiller for the development of polymer nanocomposites. Polypropylene-based polymer nano-composites reinforced with OPA along with a compatibilizer were prepared by a melt-mixing technique, using a double screw extruder. Variations in the mechanical, morphological, and ther...

Zinc sulfate monohydrate (ZnSO4)-loaded nanocomposites (NCs) were fabricated by using a hot-melt extruder (HME) system. Soluplus (SP) was adopted as an amphiphilic polymer matrix for HME processing. The micro-size of ZnSO4 dispersion was reduced to nano-size by HME processing with the use of SP. ZnSO4 could be homogeneously dispersed in SP through HME processing. ZnSO4/SP NCs with a 75 nm mean ...