BACKGROUND Breast cancer during pregnancy is often more advanced than in non-pregnant women. Nevertheless, no case of metastasis inside the placenta has been reported. Previously, we showed that placental-explants eliminated breast cancer cells from their surroundings, due to cell-death and elevated migration. Our objective was to find the underlying mechanisms of these phenomena. METHODS AND...

Three newly synthesized copper complexes: [Cu(PLSC)Cl2](1), [Cu(PLSC)(H2O)(SO4)]2.3H2O(2), [Cu2(PLSC)2(NCS)2] (NCS)2 (3) with pyridoxal semicarbazone (PLSC), as ligand, after being subjected to biological tests, showed anticancer activity. As ligand PLSC is biologically active, the results of biological activity are as expected. Specifically, an activity was demonstrated in breast cancer cells ...

Nicotine, one of the major components in tobacco, is at high concentrations in the bloodstream of cigarette smokers. However, the mechanisms of how nicotine affects tumor development and whether nicotine is a potential carcinogen for malignancies induced by secondhand smoking are not fully understood yet. Here, we investigate the signaling pathways by which nicotine potentiates tumorigenesis in...

Growing evidence indicates that alternative or aberrant pre-mRNA splicing takes place during the development, progression, and metastasis of breast cancer. However, which splicing changes that might contribute directly to tumorigenesis or cancer progression remain to be elucidated. We used splicing-sensitive microarrays to detect differences in alternative splicing between two breast cancer cel...

Chemotherapy side effects, drug resistance, and tumor metastasis hinder the progress of cancer treatments, which has led to patients having a poor prognosis. In recent years, nanoparticles (NPs) have become an emerging trend in delivery technology. The biosynthesis gold (AuNPs) from lactic acid as probiotic metabolites is cost-efficient eco-friendly approach due widespread availability ease cul...

Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the tumor suppressor genes p53/p21. In contrast to MCF7 cells that have wt p53, E...

In breast cancer cell lines, pro-cathepsin D is synthesized in excess and abnormally processed, resulting in its slower maturation and increased secretion into the culture medium. Since this lysosomal protease is only active at acidic pH, we have searched for acidic compartments other than lysosomes where cathepsin D might be active when MCF7 cells are plated on corneal extracellular matrix. We...

Multidrug resistance (MDR) is a barrier to successful cancer chemotherapy. Although MDR is associated with overexpression of ATP-binding cassette (ABC) membrane transporters, mechanisms behind their up-regulation are not entirely understood. The cleaved form of the Notch1 protein, intracellular Notch1 (N1(IC)), is involved in transcriptional regulation of genes. To test whether Notch1 is involv...

A major problem in treating cancer is the development of drug resistance. We previously demonstrated doxorubicin (DOX) resistance in K562 human leukemia cells that was associated with upregulation of glyoxalase 1 (GLO-1) and histone H3 expression. The thiazolidinedione troglitazone (TRG) downregulated GLO-1 expression and further upregulated histone H3 expression and post-translational modifica...

We have investigated the hypothesis that the antiproliferative effect of l-O-octadecyl-2-O-methylglycero-3-phosphocholine (ET-18-OCH3) is mediated through the inhibition of cellular acylation processes that control the unsaturated fatty acid complement of phospholipids. The effect of K'l -1K-<K11.i on the incorporation of radiolabeled oleic, linoleic, and arachidonic acids into MCF7 and T84 pho...