BACKGROUND Traditionally, interferon-γ (IFN-γ) was regarded as a pro-inflammatory cytokine, however, recent reports suggested role of IFN-γ in immune tolerance. In our previous report, we could induce tolerance to male antigen (HY) just by male islet transplantation in wild type C57BL/6 mice without any immunological intervention. We tried to investigate the influence of IFN-γ deficiency on tol...

The effect of an acute oral load of 2 g ethanol/kg body weight was studied in a group of male and female 10-wk-old C3H/HeNCrj (C3H/He) mice to investigate gender change throughout differences of the hepatic ethanol metabolism of mice. The following parameters were measured in the serum from 0 h to 3 h after the start of the experiment: ethanol, acetaldehyde, and acetate. Their concentrations in...

This study evaluated the possible protective effect of royal jelly (RJ) on sperm parameters and sperm malondialdehyde (MDA) concentration and in vitro fertilizing potential in nicotine (NIC) exposed male mice. Thrtiy-six male BALB/c mice were randomly divided into six groups (n = 6). Group 1 received normal saline, group 2 received 100 mg kg-1 per day RJ, groups 3 and 4 rece...

Background: ROS are free radicals that have a significant role in many of the sperm physiological processes. In the presence of polyunsaturated fatty acids such as sperm plasma membrane,ROS triggers a chain of chemical reactions called lipid peroxidation.The aim of this study was to determine and compare the concentration of MDA and NO in testicular extract of hyperprolactinemic adult male mice...

Background: cyclophosphamide is anticancer agent that has been toxic effects on male reproductive system.The antioxidant agents in imedeen such as lycophence GS and Biomarine complex play important role in preventing the direct and indirect effects of free radicals caused by CP; therefore, the purpose of this study was to evaluate the effects of Imedeen on sperm characteristics of mature male m...

Methamphetamine (meth) is a neurotoxic psychostimulant that increases monoamine oxidase (MAO)-dependent mitochondrial oxidant stress in axonal but not somatic compartments of substantia nigra pars compacta (SNc) and locus coeruleus (LC) neurons. Chronic meth administration results the degeneration SNc LC neurons male mice, MAO inhibition neuroprotective, suggesting deleterious effects chronic b...

Toll-like receptor 4 (TLR4) is known to contribute the modulation of insulin resistance and systemic inflammation seen in obesity metabolic syndrome. The present study was performed investigate fertility competence TLR4 knock out male mice (TLR4 mice) on a high-fat diet (HFD), compared normal-chow (NCD). controls included wildtype (WT) fed HFD or NCD. Six-week-old were with either NCD for 20 we...

Objective: To evaluate the effects of spearmint leaves extract on body weight, liver weight and RTWI pups in Swiss albino mice. Study Design: Experimental study Place Duration Study: Anatomy Department, Shaikh Zayed PGMI, Lahore from 1st March 2014 to 30th June 2014. Methodology: Seven male 21 female mice were used. After conception divided into control (A), low dose (B) high (C) experimental g...

This study aimed to determine the anti-inflammatory effect of seagrass (Enhalus acoroides) leaves on male mice (Mus musculus). The type research used is RAL method (completely randomized design). Male musculus) were divided into 5 treatment groups including group 1 being given 1% Na.CMC suspension as a negative control, 2 leaf extract 75 mg/kgBW, 3 mice. 100 mg/kgBW acoroides), 4 was 125 and 50...