systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in iran. a male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. at necropsy, the small intestine was edematous and congested. the spleen appeared pale. the liver was large, firm and brown. one testis was cystic and neoplastic and the remain...

Primary cutaneous amyloidosis is limited to the skin without involving any other tissue. Nodular amyloidosis is rare, and atrophic nodular cutaneous amyloidosis is even rarer. We describe the fourth case of atrophic nodular cutaneous amyloidosis by searching PubMed databases. A 52-year-old female presented to our hospital with a 2-year history of orange papules and nodules without subjective sy...

AMYLOIDOSIS is usually categorized as a degenerative process. Nevertheless, the nature and pathogenesis of this disorder remain most uncertain. Reimann, Koucky, and Eklund (1935) have classified amyloidosis in four groups: primary, secondary, tumour-forming, and associated with multiple myeloma. Tumour-forming amyloidosis is known to occur as a primary process in the tissues of the eye, urinary...

Amyloid involvement of the tongue is almost always secondary to systemic amyloidosis. Isolated amyloidosis of the tongue is relatively rare and it accounts for less than 9% of all types of amyloidosis. We are presenting a case of a 54-year-old male patient who complained of an enlarged tongue and bilateral multiple swellings on the lateral borders of the tongue, which had been there since one y...

amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abnormal protein fibrils. it may either be localized to any organ or systematically distributed throughout the body. the biochemical nature of proteins varies but the physical and tinctorial properties are shared by all the amyloidogenic proteins. in the west, it is mainly composed of amyloid light (al)...

Assessment of the peripapillary nerve fiber layer and macular thickness can be determined in ophthalmology using optical coherence tomography (OCT). Decreased nerve fiber layer thickness and macular ganglion cell thickness in optic nerve ischemia have been correlated with visual field loss. OCT allows deep optic nerve head evaluation which helps understand pathophysiology of diseases.  Furtherm...

Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...

Amyloid is an eosinophilic substance which appears “apple-green birefringence” in Congo red stained tissue sections under polarized light. This standard histological analysis is supported with immunochemistry technic using specific antibodies directed against most of the common human amyloid proteins, and also amyloid proteins can be identified with characteristic fibrillar appearance by electr...

Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and review the literature of lymph node amyloidosis discussing work-up and risk factors for systemic progression.