Tumescent anesthesia is a local anesthetic technique that consists of the infiltration of a large volume of solution with a low concentration of the local anesthetic agent and epinephrine. Its main advantages are that it achieves adequate anesthesia and a significant reduction in intraoperative and postoperative bleeding, leading to greater ease of surgery with the added benefit that it facilit...

This article discusses the anesthetic management and implications of 2 pediatric patients with a diagnosis of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis has been described as an immune-meditated syndrome that triggers the production of antibodies to the NMDA receptor: a site of action for many commonly used anesthetic agents. Symptoms of this disease...

UNLABELLED TRESK (TWIK-related spinal cord K+ channel) is the most recently characterized member of the tandem-pore domain potassium channel (K2P) family. Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic-activated K2P channel yet described. Herein, we compare the anesthetic sensitivity and pharmacologic mod...

Background: Lidocaine, the first commercialized amide local anesthetic, is still the most widely used anesthetic in some countries. It is considered as a reference for new local anesthetics. Bupivacaine, an amide-type local anesthetic, provides prolonged analgesia and is indicated when post-operative pain is anticipated. Aim: To compare efficacy of lidocaine with and without bupivacaine as a de...

PURPOSE The purpose of this survey is to evaluate current usage of local and topical anesthesia by Pediatric Dentist to evaluate the current practices. METHODS Surveys were sent to 3051 pediatric dentists asking about types of anesthetics, considerations in determining local anesthetic dosage, time used to inject a cartridge and shortcomings of topical preparations. Data were computed for per...

OBJECTIVE To analyze the effect of infiltration of local anesthetics on postoperative pain relief. DESIGN Prospective randomized double-blind trial. Setting. University Teaching Hospital in Barbados, West Indies. PATIENTS Patients undergoing total abdominal hysterectomy. Interventions. Patients were randomly allocated into one of four groups according to the wound infiltration: 1) preoperat...

INTRODUCTION Long lasting anesthesia of the soft tissue beyond the dental treatment affects patients in daily routine. Therefore a sophisticated local anesthesia is needed. The purpose of this study was an evaluation of the clinical use of epinephrine-free local anesthetic solutions in routine short-time dental treatments. MATERIALS AND METHODS In a prospective, single-blind, non-randomized a...

Selective nerve root blocks (SNRB) have been used for many years as a diagnostic tool in patients with low back pain with radicular symptoms. However the accuracy, specificity, and sensitivity of these blocks has been questioned as a screening tool for spine surgery. The utility of current SNRB techniques relies primarily on the relief of pain when local anesthetic is injected. However, patient...

The tail-flick (TF) test is the most frequently used method to measure pain levels and assess the effects of anesthesia. In this study, we performed the TF test in rats sedated via an indwelling epidural catheter and then examined the effectiveness of this method in evaluating the local anesthetic effects. First, an epidural catheter was inserted into the epidural space, and anesthetic [lidocai...