intraosseous squamous cell carcinoma is a rare type of squamous cell carcinoma that requires accurate and early diagnose which is important due to its invasive feature. this article presents a rare case report on intraosseous carcinoma in a 33-year-old patient. the case was a 33-year-old man who was referred to oral disease department of babol college of dentistry complaining of chin pain. in t...

Abstract Background Small-cell carcinoma (SMCC) of hypopharynx is an extreme rare entity in the head and neck region. It commonly arising from pulmonary origin. We report a case small-cell that caused upper airway obstruction elderly gentleman. Case presentation A 67-year-old man presented to otorhinolaryngology clinic with 4-month history worsening shortness breath stridor. He was heavy tobacc...

Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine (GalNAc) degradation of ECM components by α-N-acetylgalactosaminidase (Nagalase) which facilitates migration and invasion of cancer cells. This study aims to investigate the effects of Naga-shRNA downregula...

A survey is given of upper respiratory tract tumors in Cpb:WU (Wistar random) rats. Data were collected from ten 24- to 30-month toxicity/carcinogenicity studies and from one 12-month study. Nasal tumors may lead to dyspnea, mouth breathing, and nasal discharge. These clinical signs mainly occurred in rats bearing squamous cell carcinomas. The large nasal tumors were often osteolytic, they inva...

Green tea (Camellia sinensis) contains several bioactive compounds which protect the cell and prevent tumour development. Phytochemicals in green tea extract (mostly flavonoids) scavenge free radicals, but also induce pro-oxidative reactions in the cell. In this study, we evaluated the potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epig...

Radiotherapy is now widely used as a part of multidisciplinary treatment approaches for advanced laryngeal carcinoma and preservation of laryngeal function. However, the mechanism of the radioresistance is still unclear. Some studies have revealed that the Warburg effect promotes the radioresistance of various malignant tumors, including laryngeal carcinoma. Among the regulators involved in the...

BACKGROUND Gain of 3q26 is frequently observed in squamous cell carcinomas of mucosal origin, including those originating in the head and neck region. The human telomerase RNA component (hTERC) gene, which is located on chromosome 3q26, encodes for an RNA subunit of telomerase that maintains the length of telomeres through cellular divisions, and is activated in malignant diseases. The present ...

(1) Background: Non-squamous cell laryngeal carcinoma includes endothelial tumors, such as minor salivary gland lymphoepithelial neuroendocrine soft and hard tissue sarcomas, malignant melanomas. (2) Methods: A state-of-the-art review using the MEDLINE/PUBMED, Google Scholar, Ovid Medline, Embase, Scopus electronic databases was performed. (3) Conclusions: In order to optimize overall treatment...