There is strong circumstantial evidence that human papillomavirus is a cofactor in the development of cervical neoplasia. Systemic immunosuppression has also been implicated. A study was therefore carried out examining the relation between subtypes of human papillomavirus and local immunocompetent cells in the cervix. Colposcopically directed punch biopsy specimens were taken from normal cervix...

It has recently been shown that hapten-modified cultured Langerhans cells are able to activate small resting syngeneic L3T4+ T helper cells from nonsensitized animals. Repeated stimulation of these T cells with hapten-modified cultured Langerhans cells leads to the establishment of L3T4+ hapten-specific interleukin-4-producing T-cell lines. Here we report on further characteristics of primary h...

objective(s): the link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (gdm), but the underlying mechanisms for this phenomenon are still not clear. reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). some recent studies have provi...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

background langerhans cell histiocytosis (lch) is a rare disease in which monoclonal migration and proliferation of specific dendritic cells is seen. the disease primarily affects the bones and skin, but there is a possibility that involves other organs or appears as a multi-systemic disease. case report in oral examination of a nine-month girl, two deep wounds with a yellow membrane with appro...

AIM The aim of this study is to determine the presence and distribution of Langerhans cells in periapical lesions, and correlate this with inflammatory cell infiltration and epithelial cell proliferation. MATERIAL AND METHODS Seventy chronic dental periradicular lesions, obtained during periapical surgery from 70 patients, were included in this study, including: 46 granulomas, 18 scar tissue ...

BACKGROUND DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of Langerhans in streptozotocin (STZ)-treated mice, fed either a normal or a high-fat diet. Pdx-1 expression in the pancreas and serum insulin/glucagon concentrations were also exami...

PURPOSE To describe the MR findings in the hypothalamic pituitary area in children with Langerhans cell histiocytosis and to define those MR alterations especially associated with the risk of developing diabetes insipidus. METHODS The hypothalamic-neurohypophyseal axis was studied by sagittal and coronal 1.5 T1-weighted MR imaging in 14 children with Langerhans cell histiocytosis (five with d...

PURPOSE To characterize the cornea of individuals with Thygeson's superficial punctate keratitis (TSPK) at the cellular level by laser confocal biomicroscopy. METHODS Both corneas of three patients with TSPK referred to Yamaguchi University Hospital were imaged with a laser confocal biomicroscope. Morphological changes were evaluated for each layer of the cornea. RESULTS The number of Lange...

histiocytosis of langerhans cells (class 1 histiocytosis) consists of a range of clinical manifestations, including bone eosinophilic granuloma, hand-schüller-christian syndrome, and letterer-siwe disease. these syndromes represent a spectrum of severity and prognosis of an underlying disorder which is usually sporadic. this report describes three cases in one family, who developed the disease ...