نتایج جستجو برای: ku70

تعداد نتایج: 763  

Journal: :Proceedings of the National Academy of Sciences 2021

2008
Prafulla Raval Aleksei N. Kriatchko Sushil Kumar Patrick C. Swanson

Antigen receptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination. This process proceeds through two distinct phases: a cleavage phase in which the RAG1 and RAG2 proteins introduce DNA double-strand breaks at antigen receptor gene segments, and a joining phase in which the resulting DNA breaks are processed and repaired via the non-homologous end-joini...

Journal: :International journal of environmental research and public health 2016
Rushan Chai Lidong Huang Lingling Li Gerty Gielen Hailong Wang Yongsong Zhang

A holistic approach was followed for utilizing tetracyclines (TCs)-contaminated pig manure, by composting this with rice straw in a greenhouse for CO₂ fertilization and composted residue application. After composting, the composted residues can be applied to cropland as a supplemental source of synthetic fertilizers. The objective of this study was to determine the effect of pig manure-rice str...

Journal: :Biochemical Society transactions 2007
J A Gomez V Gama T Yoshida W Sun P Hayes K Leskov D Boothman S Matsuyama

We found that Ku70, a known DNA repair factor, has a novel function to bind and inhibit Bax (Bcl-2-associated X protein), a key mediator of apoptosis. Pentapeptides derived from the Bax-binding domain of Ku70 were cell-permeable and protected cells from Bax-mediated apoptosis. These pentapeptides were called BIPs (Bax-inhibiting peptides). BIPs may become a useful therapeutic tool to reduce cel...

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