Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given to the 119 remaining patients. Thirty-seven patients were already jaundiced before antibiotic treatment was started. Jaundice developed during treatment in 38 out of 112 patients given fusidic acid (34%) and in two out of 101 patients given other antimicrob...

Conjugated bilirubin is excreted in the urine, but unconjugated bilirubin is generally believed not to be excreted by the kidneys. The basis for this difference has not been resolved by past studies. Hoover and Blankenhorn reported that bilirubin was dialyzable only from the plasma of patients who had bilirubinuria, and that it was not dialyzable from the plasma of patients with acholuric jaund...

Detailed clinical observations by Hench (1933, 1934) established that hepatogenous jaundice ameliorated rheumatoid arthritis and fibrositis. Reports followed of remissions attending jaundice induced by the injection of bile salts and bilirubin (Thompson and Wyatt, 1938), by inoculation with infectious jaundice (Gardner, Stewart, and MacCallum, 1945), and by lactophenin (Hanssen, 1942), in addit...

Because the osteoporosis occurring in chronic cholestatic liver disease (CCLD) is associated with decreased bone formation and is reversible by liver transplantation, substances retained in plasma during cholestasis may impair osteoblast function. This hypothesis was tested using a new bioassay that measures plasma mitogenic activity (PMA) for normal human osteoblast-like (hOB) cells. In 29 jau...

It has been suggested that changes take place in human platelets when they are exposed to fluorescent light of 10.8W/m2/sec at 460 nm. Loss of ability to aggregate and increase in turnover rate have been reported. However, studies of the effect of fluorescent light on adult platelets when exposed to the level of irradiance used clinically (3.5W/m2/sec) for 60 min did not reveal this effect. A s...

Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design: Animal expe...

BACKGROUND Two devices are available for making transcutaneous estimates of serum bilirubin (SBR): the Minolta AirShields JM102 and the new SpectRx BiliCheck. OBJECTIVES (a) To measure how well the readings produced by these devices agree with SBR measured in the laboratory; (b) to estimate for each device, the proportion of infants with clinical jaundice who would require blood sampling if t...

some cases. Others have described changes varying from moderate periportal fatty degeneration to generalized fatty change with cellular necrosis (Blacklock, Guthrie, and Macpherson, 1937; Bray, 1945; Christensen and Biering-Soerensen, 1946; Giles, 1948). In addition to fatty change, Sakula (1943) noted in some cases an 'early proliferation of bile canaliculi as seen in adult cirrhosis' and that...

Materials and Methods: This two-year retrospective study of 1800 jaundiced term-neonates studied 355 cases due to ABO incompatibility divided into two groups: with and without hemolytic disease. Relation of laboratory parameters and immunohematological tests to severity of disease were studied. We did not analyze the maternal antibody titer or elusion test, and this was a limitation of the stud...

OBJECTIVE Neonatal jaundice is the result of an imbalance between bilirubin production and elimination, and our objective was to clarify the contribution of an increase in bilirubin production to hyperbilirubinemia in newborns. METHODS We measured the end-tidal carbon monoxide concentration corrected for ambient carbon monoxide concentration in 108 jaundiced newborns (total serum bilirubin le...