PURPOSE To evaluate and correlate the peaks and the fluctuation of intraocular pressure seen in the association of the ambulatory intraocular pressure curve with the water-drinking test versus the peaks and the fluctuation seen in the daily intraocular pressure curve. METHODS The sample was as follows: 77 eyes belonging to 77 patients who were divided into three groups composed of 31 eyes bel...

PURPOSE To evaluate the clinical significance of 5-S-cysteinyldopa (5-S-CD), a major intermediate in melanin synthesis, as a potential diagnostic tumor marker for uveal malignant melanoma. METHODS The levels of 5-S-CD in the serum were measured by high-performance liquid chromatography in 16 patients with primary uveal melanoma. The levels of 5-S-CD were also measured in both aqueous and vitr...

Background: Uveal melanoma (UVM) is the most common primary intraocular tumor in adults. However, identification of effective biomarker for diagnosis and treatment UVM remains to be explored. Calcium integrin-binding protein 1 (CIB1) emerging as an important factor progression. Purpose: To determine contribution CIB1 UVM. Method: Immunohistochemical staining used detect expression level, while ...

Retinoblastoma is the most common intraocular malignancy in children, with a reported incidence ranging from 1 in 15,000 to 1 in 18,000 live births. It is second only to uveal melanoma in the frequency of occurrence of malignant intraocular tumors. Pawius described retinoblastoma as early as in 1597 referred to the tumor as fungus hematodes and suggested enucleation as the primary mode of manag...

PURPOSE To access the reliability of fine-needle aspiration biopsy in harvesting a sufficient amount of viable melanoma cells to establish a cell culture and maintain a melanoma cell line from an animal model of uveal melanoma. METHODS For this study, fifteen male New Zealand albino rabbits had their right eye surgically inoculated with uveal melanoma cell line 92.1. The animals were immunosu...

PURPOSE Mucoepidermoid carcinoma is a rare variant of squamous cell carcinoma of the conjunctiva. It appears more frequently in the elderly, it is more aggressive than squamous cell carcinoma, and it has a higher recurrence rate and higher incidence of intraocular and orbital invasion. METHODS We report a case of a 74-year-old man who presented to the Emergency Department with a one month his...

OBJECTIVE To evaluate the usefulness of plaque-mounted diode-light transillumination (DLT) for the localization of episcleral plaques around intraocular tumors. METHODS A clinical case series was performed to create, evaluate, and modify diode-light plaque construction, application, and imaging. Eight patients with choroidal melanoma were offered DLT as an additional method of ophthalmic plaq...

The metastatic spread of carcinoma cells is not fully understood. Here, we compare the peripheral blood mononuclear cells (PBMC) and intraocular metastatic cells in parotid gland carcinoma with the PBMCs of healthy donors by immunohistochemistry and flow cytometry. We found Ber-EP4 tumor marker-positive carcinoma cells in the aqueous humor of the patient's right eye and a CD45 and Ber-EP4-expre...

Retinoblastoma represents approximately 4% of all pediatric malignancies and is the most common primary intraocular cancer in children. Worldwide, it is estimated that there are 5000 to 8000 newly diagnosed cases of retinoblastoma yearly. In the United States, approximately 250 to 350 cases are diagnosed each year. The first description of a child successfully treated with radiation for retinob...

purpose: to compare intraocular pressure (iop) readings measured by the ocular response analyzer (ora) with those measured by the goldmann applanation tonometer (gat) in keratoconic eyes following penetrating keratoplasty (pkp) and to evaluate the influence of anatomical and biomechanical properties of the grafts on iop measurements. methods: this cross-sectional study was conducted on 45 kerat...