conclusions conservative management is successful in the vast majority of patients with spinal headache. interventional procedures are required in a small fraction of patients for symptomatic relief. case presentation intrathecal drug delivery system (idds) was initially used for the management of chronic malignant pain; it has since been used to manage pain from other nonmalignant conditions a...

Oral delivery of peptides is severely limited by their instability and poor absorption in the gastro-intestinal tract. In contrast to co-administration strategies using medium-chain fatty acids, which recently gained regulatory approval with low oral bioavailabilities ≤ 1% (Rybelsus® Mycapssa®), efforts clinically implement systems based on nanocarriers have not been successful date. The approv...

Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due their degradation in gastrointestinal tract and low transmucosal permeation. In this study, concept of an delivery device utilizing elastomeric material presented with potential increasing absorption insulin. Absorption enhancement intestine proposed as a result self-unfolding p...

The absorption of drugs via the oral route is a subject of intense and continuous investigation in the pharmaceutical industry since good bioavailability implies that the drug is able to reach the systemic circulation by mouth. Oral dry absorption is affected by both drug properties and the physiology of the gastrointestinal tract (GIT), or patient properties, including drug dissolution from th...

Certain agents that enhance drug transport through the skin, including surfactants, bile salts, and fatty acids, have been shown to exert a similar effect on the oral mucosa. Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single ...

Polymeric microparticles can serve as carriers or sensors to instruct or characterize tissue biology. However, incorporating microparticles into tissues for in vitro assays remains a challenge. We exploit three-dimensional cell-patterning technologies and directed epithelial self-organization to deliver microparticles to the lumen of reconstituted human intestinal microtissues. We also develop ...

Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake of drug candidates when formulated as nanoparticles. PLGA nanoparticles were prepared by means of a double emulsion solvent evaporation technique and eval...