We have isolated mutations defining a new gene, tlp-1, that affect asymmetric cell fates and morphogenesis during the development of the C. elegans tail. tlp-1 mutations cause defects in the specification of asymmetric cell fates in the descendants of the T blast cell, whose polarity is controlled by Wnt signaling and cause abnormal male tail development leading to the formation of a posterior ...

BACKGROUND Sensory recovery of skin flaps is generally poor unless they are elevated as an innervated flap. The aim of this study was to elucidate if Schwann cell (SC)-like cells differentiated from adipose-derived stem cells (ASCs) could improve the cutaneous nerve regeneration in skin flaps. METHODS Microvascular island groin flaps were elevated bilaterally in 32 Lewis rats. On the right fl...

The anlagen of imaginal histoblasts in the abdominal segments of Calliphora (higher Diptera) present an interesting problem, which bears on recent concepts employed in the consideration of spatial patterning in insects. They differ from imaginal discs with respect to larval organization and activity, and in the absence of the progressive pattern of genetic determination during the larval period...

The Caenorhabditis elegans genome encodes ten proteins that share similarity with Hedgehog through the C-terminal Hint/Hog domain. While most genes are members of larger gene families, qua-1 is a single copy gene. Here we show that orthologs of qua-1 exist in many nematodes, including Brugia malayi, which shared a common ancestor with C. elegans about 300 million years ago. The QUA-1 proteins c...