Evidence for intracellular formation of amyloid fibrils in a patient with kappa light-chain myeloma is described. Amyloid fibrils were seen as intracytoplasmic inclusions within plasma cells, histiocytes, renal tubule cells, and possibly in hepatocytes. Extracellular amyloid was also present. The electron microscopic studies suggest that amyloid fibrils may form in the Golgi apparatus and withi...

A case of Erdheim-Chester disease which affected the epiphysis and showed evidence of systemic disease is presented. Clinical and histopathological similarities with other forms of disseminated Langerhans' cell histiocytosis are noted, particularly reaction of infiltrating histiocytes for S100 and HLA-DR.

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder that is characterized by proliferation of benign histiocytes, and this commonly involves the liver, spleen, lymph nodes, bone marrow and central nervous system (CNS). We report here on the CT and MR imaging findings in a case of CNS HLH that showed multiple ring enhancing masses mimicking abscess or another mass on the CT and MR imaging.

Histopathological study showed pseudoepitheliomatous hyperplasia of the epidermis and there was a granulomatous inlammatory iniltrate in the dermis composed of histiocytes, eosinophils, and polymorphonuclear cells. Globular structures with a thick, pigmented wall were seen scattered between the inlammatory cells, some of them arranged in the form of a rosary. hese structures stained with period...

A case of xanthogranulomatous inflammation of the gastric wall is reported. The lesion was associated with adherent xanthogranulomatous cholecystitis and simulated, clinically, a malignant neoplasm. Histologically, foamy histiocytes, multi-nucleated giant cells, other inflammatory cells, fibrous reaction with spindle cells and cholesterol clefts were found.

Malignant fibrous histiocytoma is a rare neoplasm composed of fibroblasts and histiocytes. It assumes several histologic forms, which account for its various names and the difficulty in its diagnosis and classification. A case thought to be the sixth malignant fibrous histiocytoma involving the larynx is presented. The treatment of choice is wide excision with close follow-up examination.

Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in infancy, although it has been seen in all age groups. We are reporting a series of 5 cases of HLH in young adult and paediatric patients identified over three years.

Xanthogranulomatous endometritis is an unusual pathological entity mimicking endometrial carcinoma. This shows sheets of foamy histiocytes alongwith other inflammatory cells. We, hereby, report a case of 45 year multigravida female with irregular menstrual history, clinically diagnosed as carcinoma and histopathologically turned out as xanthogranulomatous endometritis. So, this condition should...

A young male presented with recurrent neck swellings with initial leucocyte count of 16800/mm3, with non-caseating glands on ultrasonography neck. FNAC showed mixed cellularity with histiocytic and marked lymphophagocytosis as seen in Rosai Dorfman Disease. Immunohistochemistry demonstrated CD 25, Ki 67 and CD 68 in histiocytes. Her responded to supportive treatment alone.

Total parenteral nutrition can be complicated by the marrow sea-blue histiocytes as well as copper deficiency-related bone marrow changes. Cytoplasmic vacuoles in the erythroid and myeloid precursors raise the possibility of copper deficiency anemia. If the diagnosis is delayed, the clinical course can be complicated by neurologic deficits.