This work aimed to investigate the anti-inflammatory and the antioxidant activities of the hydroalcolic extract (HAEs) from aerial parts (stems and leaves separately) of an Algerianmedicinal plantCytisustriflorusL’Hérit. The anti-inflammatory activity is evaluated by the carrageenan induced mice hind paw edema model. Oral administration of HAEs tested at the dose of 200 and 400 mg/kg body weigh...

BACKGROUND In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids. Moreover, LA is used as a drug in a variety of diseases including inflammatory diseases. The aim of the study was to examine anti-inflammatory properties of LA metabolites. MATERIAL/METHODS The present paper rep...

OBJECTIVE The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities of the methanolic extract of Piper betle leaves (MPBL). MATERIALS AND METHODS MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and f...

BACKGROUND Sex differences have been increasingly highlighted in complex regional pain syndrome (CRPS) in clinical practice. In CRPS type I (CRPS-I), although inflammation and oxidative stress have been implicated in its pathogenesis, whether pain behavior and the underlying mechanism are sex-specific is unclear. In the present study, we sought to explore whether sex differences have an impact ...

The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat's paw edema in intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of Evans blu...

OBJECTIVE To standardize an experimental model of chronic monoarthritis induced by complete Freund's adjuvant appropriate for the analysis of the effect of walking on nociception and on joint edema. METHODS The following factors were evaluated as to monoarthritis induction: route and site of administration, number and interval of inoculations, Mycobacterium species, and animal gender. Wistar ...

OBJECTIVE The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. MATERIALS AND METHODS The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (...

The present study was designed to investigate antimicrobial and anti-inflammatory activities of four plant species from Indian origin. The antimicrobial activity of petroleum ether, chloroform, ethyl-acetate and methanol extracts of barks of Acacia nilotica, Berberis chitria, Terminalia paniculata and Madhuca longifolia were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcu...

Recently, we have reported that melittin, a major toxic peptide of the whole bee venom, plays a central role in production of local inflammation, nociception and hyperalgesia following the experimental honeybee's sting. However, the exact peripheral mechanisms underlying melittin-induced multiple pain-related behaviors are still less characterized. In the present study, we sought to investigate...