The authors report a 51-year-old women with pharmacoresistant partial epilepsy who tolerated well valproate monotherapy and in combination with several other antiepileptic drugs, but developed symptoms and signs of reversible hepatic failure under a combination of valproate and topiramate. Symptoms resolved after discontinuation of VPA. This case provides further anecdotal evidence that topiram...

present series of cases of peritonitis complicating acute appendicitis. The available biochemical evidence points to an obstructive pattern of jaundice without signs of extrahepatic block. This indicates that the jaundice is of the cholestatic type: and, as suggested by Eley et al. (1965), this is possibly a hepatotoxic effect of the infecting organism, which was E. coli in most of the previous...

Histopathological changes were observed in liver, kidney and muscles of normal, protein-malnourished, diabetic as well as both protein-malnourished and diabetic albino rats when exposed to a mixture of monocrotophos, hexachlorocyclohexane and endosulfan at varying intervals. The examination revealed hepatotoxic, nephrotoxic and muscular necrotic effects in pesticides exposed rats. Toxicity was ...

Microcystin leucine-arginine (MC-LR), is a hepatotoxic agent produced by cyanobacteria, capable of posing serious threat to the human and ecological environment. In this study, bismuth vanadate (BiVO4)/NaY-Zeolite nanocomposite was intended for degradation MC-LR in aquatic solutions. The response surface methodology (RSM) used optimize operating variables affecting removal. results showed that ...

Background Treating chronic HCV/HBV-infected patients with concomitant rheumatoid arthritis (RA) may be a challenge to the clinician. The liver disease limits to some degree the treatment for the rheumatic disease as the drugs used are hepatotoxic or at risk of infection reactivation. The aim of the study is to evaluate the particularities and the safety of RA treatment in patients with both co...

During metabolism in the liver the concentration of a drug or its metabolic products may be locally increased. This provides a theoretical basis for the large and ever-increasing number of reports of acute liver damage following drug therapy. If a drug or its metabolic product is a cellular poison we may expect a direct hepatotoxic reaction with a constant relationship to the level of drug in t...

Patients with psoriasis and chronic hepatitis C virus (HCV) infection are a therapeutic challenge. Systemic psoriasis treatment with methotrexate and acitretin can be hepatotoxic, and interferon (IFN)-alpha for treatment of HCV can worsen psoriasis. Etanercept can be successfully used in patients with psoriasis and HCV. To our knowledge, this is the first case report of etanercept used prophyla...