In the presence of inositol hexaphosphate (IHP), the ESR spectrum of each of the NO derivatives of the human HbA/cat HbA hybrid hemoglobins, a~“&~ and aZCPZH, resembles the spectrum of the parent hemoglobin that provides the a chain, particularly with respect to the intensity of the triplet hyperfine structure at g = 2.009. This observation gives support to the suggestion (Henry, Y., and Banerj...

BACKGROUND Hemoglobin is a precursor of antibacterial peptides. Our aim was to identify an antibacterial peptide in human endometrium. We tested the antimicrobial activities of hemoglobin and a derived peptide in vitro and in vivo in rats. METHODS Samples (n = 3) were scraped from the surface of endometrium. Acid-soluble proteins underwent electrophoresis followed by gel overlay assay and rev...

I N T R O D U C T I O N Gary-Bobo and Solomon (1) have proposed that the anomalous osmotic behavior of the erythrocyte is due to a decrease of the net charge of hemoglobin which occurs when the hemoglobin concentration inside the erythrocyte is raised. Employing Donnan equilibrium studies, they subsequently (2) produced evidence to show that a hemoglobin charge dependence on hemoglobin concentr...

Articles Liquid Helium-3: J. G. Daunt ................................................ 579 The low-temperature properties of the rare isotope provide a basis for a new theory of liquids. Oxygen Transport through Hemoglobin Solutions: P. F. Scholander ...................585 How does the presence of hemoglobin in wet membrane mediate an eightfold increase in oxygen passage? Changing Environment o...

ERS CHARLES P. EMERSON, M.D. , Boston CLEMENT A. FINCH, M.D., Boston ROBERT S. EVANS, M.D. , San Francisco LAWRENCE E. YOUNG, M.D. , Rochester, N. Y. OLIVER P. JoNas, Pn.D. , Buffalo JEAN P. SOULIER, M.D. , ParIs SOLOMON ESTREN, M.D., New York JAN WALDENSTROM. , M.D. , Upsala, Sweden RAMON M. SUAREZ, San Juan, Puerto Rico HEMOGLOBIN, METHEMOGLOBIN AND BILIRUBIN METABOLISM SPECIFIC OXYGEN AFFINI...

ERS CHARLES P. EMERSON, M.D. , Boston CLEMENT A. FINCH, M.D., Boston ROBERT S. EVANS, M.D. , San Francisco LAWRENCE E. YOUNG, M.D. , Rochester, N. Y. OLIVER P. JoNas, Pn.D. , Buffalo JEAN P. SOULIER, M.D. , ParIs SOLOMON ESTREN, M.D., New York JAN WALDENSTROM. , M.D. , Upsala, Sweden RAMON M. SUAREZ, San Juan, Puerto Rico HEMOGLOBIN, METHEMOGLOBIN AND BILIRUBIN METABOLISM SPECIFIC OXYGEN AFFINI...

We have studied the effect of transforming growth factor beta (TGFbeta) on erythropoiesis in cultures from adult peripheral blood, using flow cytometric enumeration of fetal hemoglobin (HbF)-containing cells. TGFbeta caused a dramatic increase in the proportions of cells that accumulated HbF together with adult hemoglobin (HbA) (F+A+ cells). This highly significant (P <.0001) increase in F+ cel...

IFFERENCES IN THE HEMOGLOBINS of the adult and the newborn have been recognized since 1866 (36). Rapid advances in this field, however, began in 1949, when Pauling and Itano (25) discovered that the hemoglobin of sickle cell disease differs from adult hemoglobin. Since that time, 8 hemoglobins have been identified, hemoglobin C (18) in 1950, hemoglobin D (14) in 1951, hemoglobin E (7, 17) and h...