In the spleen, liver, and kidneys of most mammals may be found varying quantities of yellow-brown granules and to these granules has been given the general name hemosiderin. Since the formation and location of hemosiderin coincides in time and place with the destruction of blood, the idea has become firmly established that hemosiderin represents some step in the disintegration of hemoglobin and...

Acute intermittent porphyria (AIP) is an uncommon metabolic disease that impacts multiple organs and can manifest in many ways. It often misdiagnosed due to its nonspecific symptoms. Neurovisceral signs symptoms should alert physicians consider AIP the differential after excluding more common causes. Identifying underlying cause critical preventing acute attacks, trigger avoidance optimal appro...

HEMOGLOBINEMIA AND HEMOGLOBINURIA JOSEPH F. ROSS, M.D. HEMOGLOBIN PRECIPITATION IN RENAL TUBULES. A STUDY OP ITS CAUSES AND Eppacrs. Yuile, C. L. , Gold, M. A., and Hinds, E. G.: J. Exper. Med. 82.’ 361-74, 1945. Yuile and his collaborators report a continuation of their well conceived and carefully controlled studies of the mechanism of hemoglobin excretion and its effects on the kidney. They ...

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from in vit...

The gastrodermis of Atriaster heterodus Lebedev & Paruchin, 1969 (Polyopisthocotylea), a gill parasite from Diplodus argenteus (Valenciennes, 1930), is composed of "U"-shape hematin cells and a connecting syncytium, both having cytoplasmic lamellae. These cells show outgrowths and bent folds which were sent to enclose lumen material. The trapped material was then subjected to endocytosis. The n...

The method to be described for the determination of hemoglobin depends upon the comparison, in a calorimeter, of carbon monoxide hemoglobin solutions, one of which has a known hemoglobin content. Hoppe-Seyler (1) was the first to describe carbon monoxide hemoglobin and to make use of this stable combination for estimating the hemoglobin content of blood. He devised a “double pipette” for compar...