BACKGROUND Halothane and desflurane have been shown to attenuate neuronal injury; however, the effects of these anesthetics on mitochondria are unclear. We investigated whether halothane and desflurane affect the function of mitochondria after cerebral ischemia in rats. METHODS Forty male Wistar rats were randomly divided into four groups (n = 10 each): sham group; 1.5 minimal alveolar concen...

The effects of two types of general anesthetic on the neurophysiological properties of the primate somatosensory thalamus were correlated with effects on frontal cortex electroencephalographic (EEG) power and spectral properties. Graded doses of the intravenous agent methohexital sodium (METH) were studied in 12 cells in three monkeys on a halothane baseline anesthetic. Low doses of METH (0.2-1...

Halothane and enflurane were compared in 131 children undergoing adenoidectomy with or without tonsillectomy. Anaesthesia for adenoidectomy was induced with thiopentone or Althesin and for tonsillectomy with thiopentone. The response to surgery was minimal (0-5%) during both inhalation anaesthetics. During immediate recovery, respiratory depression was more profound after enflurane than after h...

The aims of our study were to determine concentrations of wasted halothane in operating rooms and to investigate the effect of halothane pollution on liver functions of exposed personnel. The studied group included operating room personnel from the clinic of surgery, Novi Sad University Clinical Center. Surgeons were exposed to an average concentration of 29.41 mg/m, anesthesiologists to 34.60 ...

219 Abstract: The effects of repeated halothane anaesthesia on 6-10 week old male, Mus musculus albino mice weighing 29-32 g were studied. Halothane, a widely used anaesthetic, is known to be metabolised in the liver to toxic intermediates through cytochrome P4502E1 (CYP2E1). During the first week of repeated dosage, glucose-6phosphate dehydrogenase (G6PDH) activity decreased in both erythrocyt...

IT IS NOW more than two years since ~he representatives of Canadian universities reported before the Society their initial ~tudies with halothane, and in the interim the pharmacology and clinical use of halofllane have been extensiv01y investigated. Though the cardiovascular effects a halotliane and of chloroform are strikingly sfla~flar, there is as yet no,'concrete 6vidence that halothane is ...

MANY mixtures of volatile anaesthetics have been -used in the past with some success, but they are difficult to handle in the modern anaesthetic apparatus. Because of the differences in the boiling points of the components of these mixtures, they volatilize at different rates and therefore it is almost impossible to know their concentration in the anaesthetic mixture administered to the patient...

14C-halothane direct photoaffinity labeling was used to characterize the distribution of halothane binding in rat brain to test the hypothesis that anesthetics bind preferentially to a specific, heterogeneously distributed, receptor or channel. Slide-mounted sagittal rat brain sections were placed in gas-tight quartz cuvettes with 100 microM 14C-halothane in phosphate buffered saline with 0 to ...

We examined the effects of verapamil on the in vitro caffeine and halothane tests for malignant hyperpyrexia (MH) susceptibility. Ten consecutive MH-susceptible patients were investigated according to the protocol of the European MH group. Additional tests were carried out in the presence of verapamil 10(-6) mol litre-1. In four of the 10 patients, the halothane contracture response following p...

Intracellular brain pH was measured with a lipid-soluble, pH-sensitive fluorescent indicator in 16 squirrel monkeys. Eight of these were under halothane anesthesia and eight under barbiturate anesthesia. Measurements were taken before, during, and after focal incomplete ischemia. Brain pH following 3 h of cerebral focal ischemia changed from a normal value of 7.0 to 6.5 and 6.2 in animals studi...