نتایج جستجو برای: glyceryl trinitrate

تعداد نتایج: 2528  

Journal: :The Journal of clinical endocrinology and metabolism 2001
N N Chan R J MacAllister H M Colhoun P Vallance A D Hingorani

During the menstrual cycle, changes in endothelium-dependent vasodilatation have been demonstrated in conduit vessels in vivo, but responses in resistance vessels have not been studied. The aim of this study was to examine endothelium-dependent vasodilatation, the effects of local nitric oxide synthesis, and alpha-adrenergic constriction in resistance vessels during the menstrual cycle in 15 he...

Journal: :Circulation 2002
K Bennett-Richards M Kattenhorn A Donald G Oakley Z Varghese L Rees J E Deanfield

BACKGROUND Accelerated vascular disease is common in chronic renal failure (CRF) and accounts for significant mortality and morbidity. Elevated homocysteine levels may contribute by an effect on endothelial function. METHODS AND RESULTS We performed a double-blind placebo-controlled randomized crossover trial of folic acid at 5 mg/m2 in 25 normotensive children 12+/-3 (7 to 17) years of age w...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
K Büyükafşar E Demrel-Yilmaz C Göç men A Dkmen

We investigated the possibility of there being any photosensitive materials stores yielding nitric oxide (NO), and combined for the first time electrical field stimulation (EFS)- and UV light-induced relaxations in mouse gastric fundus. The tissue responded with relaxation to long wave UV light (366 nm). Repeated exposure to light decreased the fundic photorelaxation in that the initial photore...

Journal: :Circulation 2002
Ian B Wilkinson Ahmed Qasem Carmel M McEniery David J Webb Albert P Avolio John R Cockcroft

BACKGROUND Arterial stiffness is an important determinant of cardiovascular risk. Several lines of evidence support a role for the endothelium in regulating arterial stiffness by release of vasoactive mediators. We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation....

2010
May Hamza Xiao-Min Wang Tongtong Wu Jaime S Brahim Janet S Rowan Raymond A Dionne

BACKGROUND The role that nitric oxide (NO) plays in modulating pain in the periphery is unclear. We show here, the results of two independent clinical studies (microdialysis and gene expression studies) and a pilot dose finding study (glyceryl trinitrate study), to study the role of NO in the early phase of acute inflammatory pain following oral surgery. The effect of ketorolac on NO production...

Journal: :Clinical science 2001
G E McVeigh P B Allen D R Morgan C G Hanratty B Silke

Traditionally, nitric oxide-mediated alteration in blood vessel tone has been inferred from changes in flow in response to physical and pharmacological interventions using plethysmographic or ultrasonic techniques. We hypothesized that alteration in pulsatile arterial function may represent a more sensitive measure to detect and monitor nitric oxide-mediated modulation of arterial smooth muscle...

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