Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. The blood glucose level was measured 30, 60, and 120 min after immobilization stress initiation. W...

PRESENTATION J.U. is a 53-year-old man with uncomplicated type 2 diabetes who requires a commercial driver’s license (CDL) for his occupation as a truck driver and mechanic. His diabetes was controlled with increasing doses of metformin and glipizide during the first 4 years after his diagnosis. Despite nutrition counseling, diabetes education classes, and physician visits every 3–6 months, non...

In this study, mechanical activation (balland cryomilling) was successfully applied to obtain coamorphous mixtures of two BCS class II drugs, simvastatin (SVS) and glipizide (GPZ). This pharmacologically relevant combination of two drugs could produce a promising candidate for formulations intended for combination therapy of metabolic disorders. The co-amorphous SVS-GPZ mixtures (molar ratios 2...

Introduction: Costus speciosus is a common plant used for the treatment of diabetes mellitus and various other ailments in traditional medicine Sri Lanka. The present study was conducted to investigate hypoglycemic effect leaves C. both normal alloxan induced male Wistar diabetic rat models. Methods: A methanolic extract produced preliminary phytochemicals screening. Methanol further partitione...

OBJECTIVE To split several tablet products relevant to the Veterans Affairs (VA) Maryland Healthcare System and assess whether the resulting half tablets provide equal doses. METHODS From a VA list of products that are required to be split, 7 products were evaluated, along with 5 other commonly split tablet products. A trained pharmacy student split tablets using a tablet splitter provided by...