نتایج جستجو برای: genomic scan
تعداد نتایج: 195881 فیلتر نتایج به سال:
Cancer therapies have experienced rapid progress in recent years, with a number of novel small-molecule kinase inhibitors and monoclonal antibodies now being widely used to treat various types of human cancers. During cancer treatments, mutations can have important effects on drug sensitivity. However, the relationship between tumor genomic profiles and the effectiveness of cancer drugs remains...
Predicting Responses to Contemporary Environmental Change Using Evolutionary Response Architectures.
Rapid environmental change currently presents a major threat to global biodiversity and ecosystem functions, and understanding impacts on individual populations is critical to creating reliable predictions and mitigation plans. One emerging tool for this goal is high-throughput sequencing technology, which can now be used to scan the genome for signs of environmental selection in any species an...
The main functionality of the package is Position Weight Matrix (PWM) enrichment analysis in a single sequence (e.g. enhancer of interest) or a set of sequences (e.g. set of ChIP-chip/seq peaks). Note that this is not the same as de-novo motif finding which discovers novel motifs, nor motif comparison which aligns motifs. The package is built upon Biostrings and offers high-level functions to s...
Two-hundred and seventeen subjects underwent transvaginal ultrasound -17 (8%) had unilateral polycystic ovary (PCO). Twelve percent of subjects with unilateral scan-pea had oligomenorrhea, 24% were amenorrheic, 23% were hirsute and 29% had acne. Biochemical parameters were compared between subjects with unilateral scan- PCO and those with bilateral scan- PCO (n=200) as well as a group of s...
Adaptive divergence at the microgeographic scale has been generally disregarded because high gene flow is expected to disrupt local adaptation. Yet, growing number of studies reporting adaptive divergence at a small spatial scale highlight the importance of this process in evolutionary biology. To investigate the genetic basis of microgeographic local adaptation, we conducted a genome-wide scan...
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