Callera, João Carlos, Leni G. H. Bonagamba, Anne Nosjean, Raul Laguzzi, and Benedito H. Machado. Activation of GABAA but not GABAB receptors in the NTS blocked bradycardia of chemoreflex in awake rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1902–H1910, 1999.—In the present study we analyzed effects of bilateral microinjections of muscimol (a GABAA agonist) and baclofen (a GABAB agonist...

De Koninck, Yves and Istvan Mody. Endogenous GABA actition of these receptors to raise the intracellular concentration vates small-conductance K channels underlying slow IPSCs in of G proteins to the level required for activation of the K rat hippocampal neurons. J. Neurophysiol. 77: 2202–2208, 1997. channels (Destexhe and Sejnowski 1995), or 3) cause the The objective of this study was to dete...

g-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance via monocarboxylate transporter (MCT) inhibition represents a potential therapeutic strategy in GHB overdose, as does inhibition of GABAB receptors. In this study, we investigate toxicokinetic/ toxicodynamic interactions between GHB-ethanol and efficacy of treatment options for GHB-etha...

Since the introduction of the alpha function by Rall in 1967 12], there has been signii-cant progress in our understanding of the molecular events underlying synaptic transmission. Particular receptor types have been identiied and their activation kinetics characterized. It is now possible to develop models of these receptors, using a formalism similar to that introduced by Hodgkin and Huxley 9...

s (Since Jan 2004): L.H. Jacobson, K. Kaupmann, B. Bettler & J.F. Cryan. GABAB(1) receptor subunit isoforms:a role in anxiety? Poster, Society for Neuroscience, Atlanta, U.S.A., Oct. 2006. Publications194_________________________________________________________________________________ L.H. Jacobson*, B. Bettler, K. Kaupmann & J.F. Cryan. The GABAB(1a) receptor subunitisoform med...

γ-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance via monocarboxylate transporter (MCT) inhibition represents a potential therapeutic strategy in GHB overdose, as does inhibition of GABAB receptors. In this study, we investigate toxicokinetic/toxicodynamic interactions between GHB-ethanol and efficacy of treatment options for GHB-ethan...

Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong pre-clinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversial. Some evidence supports the block of α9α10 nAChRs as an analgesic mechanism, while other evid...

Isaacson, Jeffry S. GABAB receptor-mediated modulation of pre(Bennett and Ho 1991; Stanley and Mirotznick 1997; Yawo synaptic currents and excitatory transmission at a fast central synand Chuhma 1993). However, the small size of most synapapse. J. Neurophysiol. 80: 1571–1576, 1998. Large nerve termitic structures in the mammalian brain made direct electronals (calyces of Held) in the medial nuc...

We investigated expression of -aminobutyric acid (GABA), glutamate decarboxylase, and matrix metalloproteinase (MMP) in the prostates of patients with cancer or benign prostatic hypertrophy by immunohistochemical study. Marked expression of GABA, glutamate decarboxylase 67, and MMPs was observed in the prostates of cancer patients with metastasis (n 72) and lymph node metastasis, although only ...