Recent theoretical calculations predicted that Gly33 of one molecule of amyloid beta-peptide (1-42) (Abeta(1-42)) is attacked by a putative sulfur-based free radical of methionine residue 35 of an adjacent peptide. This would lead to a carbon-centered free radical on Gly33 that would immediately bind oxygen to form a peroxyl free radical. Such peroxyl free radicals could contribute to the repor...

in this study, we measured the composition and free radical scavenging activity of several species of nuts, namely, torreya grandis, carya cathayensis,and myrica rubra. the nut kernels of the aforementioned species are rich in fatty acids, particularly in unsaturated fatty acids, and have 51% oil content. t. grandis and c. cathayensis are mostly produced in zhejiang province. the trace elements...

background: brucella species can cause infection in a wide range of animals and human beings. oxidative events against brucella infection are not well elucidated. it is possible that brucellosis may be related to increased free radical production and antioxidant depletion. thus, the aim of this study was to determine the total antioxidant capacity (tac) before and after treatment of patients wi...

BACKGROUND The recent literature suggests that free radicals and reactive oxygen species may account for many pathologies, including those of the nervous system. MATERIALS AND METHODS The influence of various reactive oxygen species on the rate of glutamate uptake by astrocytes was investigated on monolayers of primary cultures of mouse cortical astrocytes. RESULTS Hydrogen peroxide and per...

Polymorphonuclear leukocytes and other inflammatory cells release superoxide anion and additional oxidant species following stimulation. Corneal endothelial cells were exposed to a flux of chemically generated superoxide anion (oxygen-free radical) produced by the combination of 1 mM hypoxanthine and 0.06 U/ml xanthine oxidase. Exposure of endothelial cells to the combination of hypoxanthine an...

ion, hydrogen addition or electron transfer, while superoxide anion reacts via only hydrogen abstraction and electron transfer (Section 1.2) (5). Although, hydrogen peroxide and singlet oxygen are classified as ROS, they are not radicals and do not necessarily interact with tissue through radical reactions directly (6). Hence, they are not toxic per se but in presence of free radicals or cataly...

Brain tissue being rich in polyunsaturated fatty acids, is very susceptible to lipid peroxidation. Iron is well known to be an important initiator of free radical oxidations. We propose that the principal route to iron-mediated lipid peroxidations is via iron-oxygen complexes rather than the reaction of iron with hydrogen peroxide, the Fenton reaction. To test this hypothesis, we enriched leuke...

The effect of allyl isothiocyanate (AITC) on radical scavenging capacity, and fruit decay of blueberries var. Duke (Vaccinium corymbosum L.) was evaluated. Results from this study showed that AITC was effective in retarding blueberry decay during storage at 10 C. However, AITC-treated fruit decreased the contents of total phenolics and anthocyanins. Compared to control, AITC-treated berries had...

In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds' bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results w...