The accumulative roll bonding (ARB) as a severe plastic deformation (SPD) procedure aimed at enhancing the mechanical properties of metals and alloys. In the present study, a new slab method is proposed for estimating the forming stress field for cold extrusion of metals cross the alumina interlayer powder particles by accumulative roll bonding process. Plastic deformation behavior of the metal...

The present paper deals with numerical comparison of two twist-based severe plastic deformation processes: (i) the elliptical cross-section spiral equal-channel extrusion (ECSEE) proposed recently as a novel process and (ii) the classical twist extrusion (TE). ECSEE was developed in attempt to process cylindrical work pieces and to generate more uniform strain distribution compared to classical...

When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P₂ receptors in neighboring cells that seamlessly squeeze the cell out of the epithelium. Here, we find that extrusion defects can contribute to carcinogenesis and tumor progression. Tumors or epithelia lacking S1P₂ cannot extrude cel...

Preparation of monodisperse vesicles is important both for research purposes and for practical applications. While the extrusion of vesicles through small pores (approximately 100 nm in diameter) results in relatively uniform populations of vesicles, extrusion to larger sizes results in very heterogeneous populations of vesicles. Here we report a simple method for preparing large monodisperse m...