A gradient reversed phase HPLC method was developed and validated for analysis of betamethasone dipropionate, its related substances and degradation products, using Altima C(18) column (250×4.6 mm, 5 μm) with a flow rate of 1.0 ml/min and detection wavelength of 240 nm. The mobile phase A is a mixture of water, tetrahydrofuran and acetonitrile in the ratio of 90:4:6 (v/v/v) while mobile phase B...

A simple, precise, and accurate, isocratic, reversed RP-HPLC stability indicating method was developed and validated for determination of Nabumetone (Naphthyl acetic acid derivative). Isocratic RP-HPLC separation was achieved on Inert Sil ODS 3V (5μ, 25 cm× 4.6 mm, i.d.) column using mobile phase consisted of 0.47 g of tetrabutyl ammonium hydroxide sulphate (TBAH) dissolved in 1000 ml of a mixt...

A new stability-indicating RP-HPLC assay method was developed and validated for quantitative determination of loteprednol etabonate in bulk drugs and in ophthalmic suspensions in the presence of degradation products generated from forced degradation studies. The system consisted of Agilent Technologies Zorbax Eclipse XDB-Phenyl 5 µm 4.6 × 250 mm, and detection was performed at 244 nm. The mobil...

Trans-activation of the activating transcription factor-2 (ATF2) in response to cellular stress requires the N-terminal phosphorylation of ATF2 by stress-activated protein kinases (SAPK). In this study, we investigated the role of ATF2 phosphorylation in the maintenance of ATF2 stability. Activation of SAPK by forced expression of DeltaMEKK1 increased overall ATF2 ubiquitination, presumably bec...

An analytical model is developed for cellular networks with a combined adaptive bandwidth allocation and trafficrestriction mechanism. Instead of focusing only on the bandwidth utilization and forced-termination probability, we derive two important Quality-of-Service (QoS) metrics, degradation ratio and upgrade/degrade frequency. We show numerically that these two metrics must be taken into acc...

A detailed investigation of Valsartan`s light-induced degradation is reported. Based on UPLC-HRMS studies stressed solutions several pathways are proposed. Some the proposed structures were obtained by forced experiments. Examination analytical data including crystal allowed for structural revision one literature-known degradant. In addition, irradiation under aerobic conditions revealed furthe...

A catastrophic extinction occurred at the end of the Permian Period. However, baseline extinction rates appear to have been elevated even before the final catastrophe, suggesting sustained environmental degradation. For terrestrial vertebrates during the Late Permian, the combination of a drop in atmospheric oxygen plus climate warming would have induced hypoxic stress and consequently compress...

This paper proposes a newly developed priority based call admission control algorithm, that performs the all the decision making regarding which strategies to adopt in order to successfully serve a new user, even if the load level in the corresponding cell is above a defined threshold. The combination of methods such as forced handover, queue list and service degradation allows for a customizab...

The recent improvement of infrared image quality has increased the use thermography as a non-destructive diagnostic technique. Amongst other applications, can be used to monitor historic buildings. present work was carried out within framework Horizon 2020 European project SHELTER, which aims create management plan for cultural heritage subject environmental and anthropogenic risk. Among chosen...