In the title compound, C(15)H(10)FIO(2)S, the O atom and the 4-fluoro-phenyl group of the 4-fluoro-phenyl-sulfinyl substituent are located on opposite sides of the plane through the benzofuran fragment; the 4-fluoro-phenyl ring is nearly perpendicular to this plane, making a dihedral angle of 83.37 (7)°. The crystal structure is stabilized by weak inter-molecular C-H⋯O hydrogen bonds and an I⋯O...

A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for development of inhibitors poly(ADP-ribose) polymerase (PARP). Synthesis 3,4-dihydroisoquinol-1-one-4-carboxylic acids achieved using previously developed protocol based on modified Castagnoli-Cushman reaction homophthalic anhydrides and 1,3,5-triazinanes formaldimine synthetic equivalents. Employment 2,4-dim...

Fluoro-Jade B, a marker of degenerating neurons, was used to label histopathological changes in the rat spinal cord after transient ischemia and ischemic preconditioning (IPC). To characterize postischemic neurodegenerations and consequent neurological changes, a particular attention was paid to the standardization of ischemic conditions in animals of both groups. 1. The control ischemic rats w...

Computer-assisted surgery, which provides simultaneous, multiplanar images of bone structures, has become widely used. However, registration maneuvering remains time consuming. The objective of this paper is to document the usefulness of CT-fluoro matching for spinal navigation. A spinal navigation system (VECTORVISION compact; Brain LAB, Germany) and a digital imaging system (OEC9800; CATHEX, ...

The metabolism of 5-fluorouracil (511) in tumors and livers of RII -1 tumor-bearing C3H mice given i.p. injections of 5FU was serially moni tored by "F magnetic resonance spectroscopy. The levels of 5FU and fluoronucleotide detected in the tumors after a dose of 130 mg/kg (n = 13) »ereless than one-third of those after 260-mg/kg 5FU (n = 14). During the days after these doses, tumor size decre...