OBJECTIVE To investigate the contribution of promoter methylation-mediated epigenetic events in recurrent respiratory papillomatosis tumorigenesis. DESIGN Archival tissue DNA, extracted from microdissected papilloma lesions, was interrogated for methylation status by means of the novel, multigene methylation-specific multiplex ligation-dependent probe amplification assay. SUBJECTS Fifteen s...

Papillomavirus oncogenesis as a benign process, clinically diagnosed papillomatosis, is common in small domestic animals, particular among cats and dogs, but the nosological structure of neoplasms has different ratio depending on species. Recent data indicate provocation precancerous neoplastic lesions species by papillomatosis virus. Clinically, associated with skin mucous membranes, which det...

UNLABELLED Vascular abnormality of the intestine is rare, except angiodysplasia. We report on an unusual case of atypical florid vascular proliferations of the appendix. A 41-year old male presented with melena. Adhesioned blood clots in the appendiceal orifice were observed by colonoscopy. He underwent laparoscopic appendectomy. Microscopically, a tiny exophytic polypoid mass was observed. The...

OBJECTIVE Is skin-sparing mastectomy (SSM) with conservation of the Nipple-Areola Complex (NAC) and immediate autologous reconstruction as safe in oncologic terms as SSM with resection of the NAC as modified radical mastectomy (MRM)? SUMMARY BACKGROUND DATA The originally described technique of SSM included the removal of gland, NAC, and biopsy scar. However, the risk of tumor involvement of ...

Introduction: Nipple creation using the C-V flap technique is often the final step in breast reconstruction. The aim of this study was to assess subjectively and objectively the cosmetic outcomes and satisfaction of patients undergoing C-V flap nipple reconstruction. Methods: Subjective assessments of patient satisfaction with the neo-nipple recorded by visual analogue scoring (VAS; 0-10). Obje...

OBJECTIVE To present the findings of computed tomography (CT) scans of the chest in patients with laryngotracheobronchial papillomatosis. METHODS We retrospectively analyzed CT scans of eight patients, five males and three females, ranging from 5 to 18 years of age with a mean age of 10.5 years. Images were independently reviewed by two radiologists. In discrepant cases, a consensus was reach...