The identification of etiological agents in feral fish neoplasia epizootics has been hampered in part by the lack of suitable fish models, and complicated by the likely existence of environmental agents which can act to stimulate or reduce population responses to genotoxin insult. The response of fish to tumor inhibitors and promoters, and the underlying mechanisms of modulation, have been stud...

Undoubtedly, breast milk enjoys the best nutrient combination for the growth of human children (1). Exclusive breast feeding has also been reported in the first 4 and 6 months of life in 57% and 28% of infants, respectively (2). Low and dried-up milk supply are of the major problems encountered in breastfeeding, for which some mothers, despite their propensity, are not able to breastfeed their ...

High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s-70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and...

The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of receptors related to the mammalian pregnane X receptor (PXR) (NR1I2) and constitutive androstane receptor (CAR) (NR1I3). We have carried out an extensive comparative analysis of this subgroup with representatives from fish, birds, amphibians, and mammals. Four novel receptors were isolated from fish, dog, pig, ...

aretaeus of cappadokia, lived in an era when cancer was already a disease, well known for its deadly outcome. inside his momentous treatise, composed of 8 books, he had outlined various types of cancer. he had understood cancer’s fatality and proposed some curative treatments. our manuscript composes the fragments related to cancer, in an effort to present aretaeus’ views on the matter.  he had...

Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, by assessing flux across model membranes. Eudragit E, Soluplus, a therapeutically used polymer, Colesevelam,...

Unconjugated bile acids in the bile of healthy and diseased humans were determined qualitatively and quantitatively by means of gas-liquid chromatography and gas-liquid chromatography-mass spectrometry, after their isolation by ion-exchange chromatography. In a healthy person and three patients with cholelithiasis, unconjugated bile acids comprised 0.1-0.4% of total biliary bile acids. The bile...

objective(s): gastroesophageal reflux disease (gerd) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. in the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspiratio...

colloid carcinoma, also called mucinous carcinoma, is classified as a histologic variant of adenocarcinoma. because the colloid carcinoma of the biliary tree is exceedingly rare, the imaging characteristics and the clinical features of colloid carcinoma remain relatively unknown. we report a case of colloid carcinoma of the common bile duct and its accompanied metastatic lymphadenopathies with ...