نتایج جستجو برای: fatty acid elongase gene
تعداد نتایج: 1796572 فیلتر نتایج به سال:
Background and Objective: Atheroma formation and progression of atherosclerosis are dependent on the expression of bone matrix proteins and regulatory factors such as osteonectin in the vessel walls. Studies have shown that consumption of Trans fatty acids increase risk of cardiovascular diseases. In this study, the effect of elaidic acid on osteonectin gene expression as one of the vascular ca...
BACKGROUND Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. SCD1 has been repeatedly implicated in the pathogenesis of metabolic and inflammatory diseases. Therefore it is of great importance to determine SCD1 activity in human samples. In this study we aimed to evaluate a...
The synthesis and accumulation of omega-3 long-chain polyunsaturated fatty acids in transgenic Camelina sativa is demonstrated using the so-called alternative pathway. This aerobic pathway is found in a small number of taxonomically unrelated unicellular organisms and utilizes a C18 Δ9-elongase to generate C20 PUFAs. Here, we evaluated four different combinations of seed-specific transgene-deri...
Background: Antisense peptide nucleic acids (PNAs) exhibit growth inhibitory effects on bacteria by inhibiting the expression of essential genes and could be promising therapeutic agents for treating bacterial infections. A study was carried out to determine efficacy several antisense PNAs in extracellular intracellular Mycobacterium smegmatis. Methods: Six obtained from a commercial supplier w...
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA synthesis. Increasing hepatic Elovl5 activity in obese mice lowered hepatic TGs and endoplasmic r...
زئوپلانکتون¬ها گروه بسیار مهمی از موجودات زنده بوده که پایه زنجیره غذایی را در اکوسیستم¬های آبی تشکیل می¬دهند. از بین آن¬ها کلادوسرها و کپه¬پودها نقش مهمی را در زنجیره غذایی آبها داشته و از طریق تغذیه روی انواع موجودات زنده آبزی، انرژی را از میکروالگ¬ها به سطوح بالای هرم غذایی انتقال می¬دهند. همچنین زئوپلانکتون¬ها منابع ارزشمندی از پروتئین¬ها، اسیدهای آمینه، لیپیدها، اسیدهای چرب، ویتامین¬ها و آ...
BACKGROUND Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-) polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be converted (utilizing desaturase and elongase enzymes encoded by FADS and ELOVL genes) to biologically-active long chain (LC; >20)-PUFAs by numerous cells and tissues. These n-6 and n-3 LC-PUFAs and their metabolites (ex, eicosano...
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