Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downregulation of surface CD46 was documented during the course of HHV-6 infection. B...

Human herpesvirus 6 (HHV-6) is known since 1986 but the clinical disease exanthema subitum was described already in 1910. HHV-6 is a typical herpesvirus and also has the characteristic herpes group features, latency, tendency to reactivations, and neurotropism. In addition, it has an intriguing property to modulate immune response and to interact with other viruses, and alter their natural cour...

Background Type IV drug hypersensitivity reactions with cutaneous manifestations (cADR) are highly variable in clinical appearance and degree of severity, ranging from maculopapular exanthema (MPE) to more severe disorders such as DRESS or SJS/TEN. Recent studies show NKp46+ cells in skin of drug-induced exanthemas, and NK cells expressing granulysin have been found in blister fluids from SJS/T...

explains the various options available for diagnosis and treatment of clinical disease syndromes in horses caused by alpha herpesviruses EH1 and EH4 THERE are nine different equine herpesviruses (EHVs) – EHV1 to EHV5 infect the domestic horse, while EHV6 to EHV9 are associated with infections in wild equids, including asses and zebra. The alpha herpesviruses EHV1 and EHV4 are respiratory pathog...

Agents not discussed are the following: rotavirus infections under natural conditions they usually do not cause diarrhea and piglets become disease resistant early in life; vesicular exanthema not present in Europe; adenovirus infectionsthey are mostly isolated from piglets without clinical symptoms; inclusion body rhinitis (cytomegalovirus) usually only described outside Europe without relevan...

RNA labeled with [3H]uridine from Vero cells infected with San Miguel sea lion virus in the presence of actinomycin D was analyzed by glycerol density gradient sedimentation and polyacrylamide gel electrophoresis. The predominant single-stranded RNA (36S, 2.6 x 10(6) molecular weight) was genome size. There was also a prominent 22S, 1.1 x 10(6)-molecular weight, single-stranded component and on...

The International Committee on Taxonomy of Viruses (ICTV) has recently approved several proposals submitted by the present Caliciviridae Study Group. These proposals include the division of the family into 4 new genera designated Lagovirus, Vesivirus, "Norwalk-like viruses (NLVs), and "Sapporo-like viruses (SLVs); the latter 2 genera were assigned temporary names until acceptable names can be d...

CAD: chronic actinic dermatitis JAK: Janus kinase TCR: T cell receptor UV: ultraviolet INTRODUCTION Chronic actinic dermatitis (CAD) is an uncommon inflammatory dermatosis characterized by dermatitis involving ultraviolet (UV) lighteexposed skin with notable sparing of sun-protected areas. Rarely, spread of the exanthema to UV-protected areas of skin and even erythroderma with palmoplantar hype...

Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessels' vasculitis that affects the skin, intestines and kidneys. Pregnancy has been reported as an exacerbating factor. We present the case of a 24-year-old primigravida with HSP that occurred in the third trimester and lasted up to the end of the successful delivery. She had pruritic maculopapular exanthema on her legs. Biopsy of a cuta...

Chikungunya virus infection is a disease transmitted by vectors, in which vertical transmission was described in years 2005-2006. An infection rate up to 49% in neonates born from mothers with active viremia during labor has been observed. Perinatal infection could results in serious complications and potential cognitive impairment. OBJECTIVE To describe a newborn with Chikungunya virus infec...