The commentary by Boettger-Tong et al. (1) described the authors' experience with a commercially available, unidentified rodent diet with high estrogenic activity and the impact of this diet on the normal in vivo uterotropic response of ovariec-tomized 30-day-old Sprague-Dawley rats to exogenously administered estradiol. The purpose of this letter is to corroborate the authors' findings; to rep...

Urine has great potential to be an effective fertilizer due its high nutrient content, however, it can contain potentially worrying pharmaceuticals. Our objective was study whether urine storage and aerobic biological treatment, i.e. nitrification, sufficient remove pharmaceuticals or additional treatment with activated carbon necessary produce a from urine. We investigated the abatement of twe...

Use of estrogen or estrogen/progestin combination was an approved regimen for menopausal hormonal therapy (MHT). However, more recent patient-centered studies revealed an increase in the incidence of breast cancer in women receiving menopausal hormone therapy with estrogen plus progestin rather than estrogen alone. Tissue selective estrogen complex (TSEC) has been proposed to eliminate the prog...

Natural estrogen, estrone (E1) is one of the most potent endocrine disrupting compounds (EDC). It is of primary concern due to its widespread presence in the aqueous environment and also due to its adverse impact both on aquatic life and potential risk to human health. Conventional waste water treatment plants are not designed to remove it, and most of it remains adsorbed on the activated sludg...

To further develop an integrated in vitro testing strategy for replacement of in vivo tests for (anti-)estrogenicity testing, the ligand-modulated interaction of coregulators with estrogen receptor α was assessed using a PamChip® plate. The relative estrogenic potencies determined, based on ERα binding to coregulator peptides in the presence of ligands on the PamChip® plate, were compared to th...

Enterolactone (EL) is an enterolignan produced by gut microbiota from dietary plant lignans. Epidemiological and experimental studies suggest that EL and plant lignans may reduce the risk of breast and prostate cancer as well as cardiovascular disease. These effects are thought to at least in part involve modulation of estrogen receptor activity. Surprisingly little is known about the in vivo e...

Estrogenicity of Environmental PCBs The paper by Bergeron, Crews, and McLachlan, "PCBs as Environmental Estrogens: Turtle Sex Determination as a Biomarker of Environmental Contamination" (EHP 102:780-781) presents data on the estrogenic activity of 11 chlorinated biphenyls or diphenyl ethers, or hydroxylated derivatives thereof, selected so as to represent a variety of structural types. Some of...

THE profound changes in the serum lipids resulting from estrogen administration to men and women with coronary heart disease have been documented in several laboratories.1-6 But these presumably "favorable " alterations have been offset by undesirable estrogenic side-effects, especially in middle-aged men.3'4 Among many measures suggested to avoid the side-effects, including very low estrogen d...